Review Article Volume 8 • Issue 4 379 Clinical Predictors of Cardiac Arrest among COVID-19 Patients with Heart Failure Bharat Marwaha 1* , Indrajeet Mahata 2 , Navneet Kumar 3 , Goldendeep Singh 4 , Amod Amritphale 5 Affiliation: 1 Director Advanced Cardiac Imaging, Adena Medical Center, Affiliate of Ohio State University, OH, USA 2 Cardiac Electrophysiologist, Mercy Health, Spring field, MO, USA 3 Noninvasive Cardiology, Oakland Trinity Hospital, MI, USA 4 Modesto Hospital, California, USA 5 Interventional Cardiologist, Mercy Health, Spring field, MO, USA *Corresponding authors: Bharat Marwaha, Director Advanced Cardiac Imaging, Adena Medical Center, Affiliate of Ohio State University, OH, USA. Citation: Bharat Marwaha, Indrajeet Mahata, Navneet Kumar, Goldendeep Singh, Amod Amritphale. Clinical Predictors of Cardiac Arrest among COVID-19 Patients with Heart Failure. Cardiology and Cardiovascular Medicine. 8 (2024): 379-388. Received: July 27, 2024 Accepted: August 02, 2024 Published: August 22, 2024 Abstract The COVID-19 pandemic has impacted the healthcare system across the globe, leading to more than 6.9 million deaths in the past four years. Cardiac Arrest is a terminal event with associated significantly high morbidity and mortality across age groups. Multiple clinical parameters, organ dysfunction, and chronic co- morbid conditions impact mortality in COVID-19 patients with heart failure. In this retrospective, administrative dataset-based study on 148899 patients admitted to the hospital with COVID-19 and heart failure diagnosis, we reported 6703 cardiac arrests and 5783 mortality. We have used ICD 10 codes to identify the diagnosis. The primary objective of the study is to find the predictors of Cardiac Arrest among patients admitted to hospitals with COVID-19 and heart failure. Secondary objective is to calculate the percentage of cardiac Arrest and mortality across the various age groups and the correlation of hours on the mechanical ventilator and mortality. Study results have shown that the use of a mechanical ventilator has the strongest co-correlation with cardiac Arrest with an odd ratio of 14.4, followed by septic shock with an odd ratio of 5.6, tension pneumothorax with an odd ratio of 4.9 preceding the acute renal failure with an odd ratio of 2.4 and sepsis 2.3. Complete heart block had an odd ratio of 1.9, followed by ESRD with a ratio of 1.6, acute pulmonary embolism with an odd ratio of 1.5, and Type 2 MI with an odd ratio of 1.49. Chronic co-morbid condition of DM had an odd ratio of 1.3, followed by Atrial fibrillation with an odd ratio of 1.1. These results and findings emphasized that multi-organ failure has a huge impact on cardiac Arrest among COVID-19 patients with heartfailure. Keywords: COVID-19; Heart failure; Cardiac arrest; DM Introduction COVID-19 pandemic has significantly impacted the healthcare systems across the world in the past few years. The COVID-19 pandemic has infected more than 760 million and led to more than 6.7 million deaths worldwide [1]. In multicenter retrospective study involving 3000 patients with confirmed SARS-CoV-2 infection, prevalence of heart failure was 10.1% [2]. Multicenter study in Italy has reported HF as an independent predictor of mortality and risk factor for in-hospital complications including acute renal failure (28.1% vs. 12.9%, P < 0.001), multi-organ failure(15.9% vs. 5.8%, P = 0.004) and sepsis (18.4% vs. 8.9%, P = 0.006) Acute heart failure has been reported in 9.1% of patients with almost 50% of them having newly diagnosed heart failure in this study [3]. Heart failure has been reported to be one of the strongest predictor for in-hospital admission [odds ratio(OR), 4.43; 95% confidence interval(CI),