Jurnal Analis Medika Biosains (JAMBS) Vol.9, No.1, Maret 2022, pp. 54 - 59 ISSN: 2656-2456 (Online) ISSN: 2356-4075 (Print) Journal homepage: http://jambs.poltekkes-mataram.ac.id/index.php/home/index PROFIL DIFFERENTIAL COUNT PADA PENDERITA HEPATITIS B DI RSUD PATUT PATUH PATJU KABUPATEN LOMBOK BARAT Aini 1 , Ika Nurfajri Mentari 2 , Laelatur zahrah 3 1 Profil Teknologi Laboratorium Medik, Politeknik Medica farma Husada Mataram, Indonesia Article Info ABSTRACT Article history: Received Des 26 th , 2020 Revised Jan 26 th , 2021 Accepted jul 2 th , 2021 Hepatitis B is a systemic disease that attacks the liver caused by the Hepatitis B virus, this diseaseis contagious. Hepatitis is still a health problem in the world, especially in developing countries including Indonesia. Hepatitis B can be detected by immunochromatography and followed by a differential count. The purpose of this study was to determine the profile of the differential count / type of leukocyte count in patients with Hepatitis B. This study was descriptive and analytical observational using a cross sectional analytical research design. The study was conducted at Patut Patuh Patju Hospital on 48 samples of hepatitis patients with positive HBsAg. The results obtained in the form of a Differential count examination for normal types of leukocytes Basophils 46 people (95.83%) Eosinophils 12 people (25%) Neutrophils 19 people (39.59%) Lymphocytes 9 people (18.75%) Monocytes 35 people (72.91%) . For the type of basophils that did not experience a decrease in the frequency of 0 (0%), and that experienced a decrease in eosinophils 26 people (54.16%) neutrophils 1 person (2.08%) lymphocytes 39 people (81.25%) monocytes1 person (2, 08 %). The types of leukocytes that experienced an increase in basophils were 2 people (4.16%) eosinophils 10 people (20.83%) neutrophils 28 (58.33%) lymphocytes 0 (0%) monocytes 12 people (25%). Keyword: Hepatitis B, differential count, leukocyte ABSTRAK Hepatitis B merupakan penyakit sistemik yang menyerang organ hati yang disebabkan oleh virus Hepatitis B, penyakit ini bersifat menular. Hepatitis masih menjadi masalah kesehatan di dunia terutama di Negara berkembang termasuk Indonesia. Hepatitis B dapat dideteksi dengan pemeriksaan immunokromatografi dan dilanjutkan dengan pemeriksaan differential count. Tujuan penelitian ini adalah untuk mengetahui profil differential count / hitung jenis leukosit pada penderita Hepatitis B. Penelitian ini bersifat Deskriptif Observasional Analitik dengan menggunakan desain penelitian Cross Sectional Analitik. Penelitian dilakukan di RSUD Patut Patuh Patju terhadap 48 sampel pasien hepatitis dengan HBsAg positif. Hasil yang didapat berupa pemeriksaan Differential count untuk jenis leukosit yang normal Basofil 46 orang (95,83%) Eosinofil 12 orang (25%) Neutrofil 19 orang (39,59%) Limposit 9 orang (18,75%) Monosit35 orang (72,91%). Untuk jenis basofil tidak mengalami penurunan frekuensi 0 (0%), dan yang mengalami penurunan eosinofil 26 orang (54,16 %) neutrofil 1 orang (2,08%) limposit 39 orang (81,25 %) monosit 1 orang (2,08 %) .Jenis leukosit yang mengalami peningkatan basofil 2 orang (4,16%) eosinofil 10 orang (20,83 %) neutrofil 28 (58,33 %) limposit 0 (0%) monosit 12 orang (25 %). Kata kunci : Hepatitis B, differential count,leukocyte