Citation: Vaishanvi Vilas Jadhav, Waghmare S. U, Kishan A. Kukar, Abhishek T. Walunje (2024). Formulation & Evaluation of Herbal based Mouthwash Effective against Common oral Bactria. Saudi J Biomed Res, 9(4): 51-62. 51 Saudi Journal of Biomedical Research Abbreviated Key Title: Saudi J Biomed Res ISSN 2518-3214 (Print) |ISSN 2518-3222 (Online) Scholars Middle East Publishers, Dubai, United Arab Emirates Journal homepage: https://saudijournals.com Review Article Formulation & Evaluation of Herbal based Mouthwash Effective against Common oral Bactria Miss. Vaishanvi Vilas Jadhav 1* , Waghmare S. U 2 , Mr. Kishan A. Kukar 1 , Mr. Abhishek T. Walunje 1 1 UG Scholar of Rashtriya College of Pharmacy Hatnoor, Tq. Kannad Dist. Chh. Sambhajinagar, Maharashtra, India -431103 2 Assistant Professor of Rashtriya College of Pharmacy Hatnoor, Tq. Kannad Dist. Chh. Sambhajinagar, Maharashtra, India -431103 DOI: 10.36348/sjbr.2024.v09i04.002 | Received: 10.05.2024 | Accepted: 21.06.2024 | Published: 28.06.2024 *Corresponding author: Miss. Vaishanvi Vilas Jadhav UG Scholar of Rashtriya College of Pharmacy Hatnoor, Tq. Kannad Dist. Chh. Sambhajinagar, Maharashtra, India -431103 Abstract In many places around the world, indigenous communities use traditional medicine as a big part of their culture and understanding of health. Guava leaves have been traditionally used to treat various illnesses like rheumatism, diarrhea, diabetes, and cough. This study looks at how guava leaves can fight fungi and bacteria. Making a herbal mouthwash with guava leaves could be a good idea for keeping our mouths clean. To make the mouthwash, we boil guava leaves to get the helpful compounds. We can also add other herbs like mint to make it even better at killing germs. After brushing your teeth, you can use this mouthwash twice a day for about 30 seconds each time to keep your mouth healthy and fight off common mouth bacteria. Herbal mouthwash is made from plant extracts instead of chemicals. It's better because it doesn't irritate or stain, and it doesn't have alcohol [1]. Guava leaves have many helpful compounds that fight bacteria, like Flavonoids, Eugenol, Terpenoids, and Linalool. These compounds help make guava leaves a good choice for a mouthwash. Making this herbal mouthwash involves a lot of steps: researching, understanding, developing, extracting, testing, refining, consulting experts, packaging, and storing. Keywords: Guava leaves, Mouthwash, mint leaves, Benzoic acid. Copyright © 2024 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited. INTRODUTION Guava, also known as Psidium guajava, is packed with important nutrients. Originally from South Africa, it was brought to India by the Portuguese. Guava leaves are commonly used in Asian countries and are prized in Western countries for their medicinal benefits. Guava trees are small in size. Guava belongs to the Myrtaceae family and thrives in tropical or subtropical climates. India is the top guava producer, followed by China. Guava leaves are typically 3 to 4 inches long [2]. Almost every part of the guava plant has medicinal qualities, making it popular in the Philippines and approved by the Department of Health as a medicinal plant. Guava is a small tree that can reach up to 3 meters in height. Its fruit, bark, and leaves are used for herbal medicine. A decoction of guava leaves is known for treating chronic diarrhea and gastroenteritis. It's also used to clean wounds and for vaginal and uterine issues. Guava leaf decoction can be used as a mouthwash too. Guava has been used to manage toothaches, sore throats, and inflamed gums [3]. Figure 1: Common Name:- Guava Leaves; Scientific Name:-Psidium guajava; Family Name:- Myrtacea