_____________________________________________________________________________________________________ *Corresponding author: E-mail: emekamaduabuchi10@gmail.com; J. Sci. Res. Rep., vol. 29, no. 7, pp. 43-56, 2023 Journal of Scientific Research and Reports Volume 29, Issue 7, Page 43-56, 2023; Article no.JSRR.101281 ISSN: 2320-0227 Assessment of Factors Influencing Process Safety Risk Accumulation in Petroleum Operations in Nigeria Emeka Maduabuchi a* , John N. Ugbebor a and Gogomari I. Oyet a a Center for Occupational Health, Safety and Environment, University of Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JSRR/2023/v29i71759 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/101281 Received: 03/04/2023 Accepted: 08/06/2023 Published: 15/06/2023 ABSTRACT A cross-sectional exploratory assessment of the factors that influence process safety cumulative risk for accident prevention in petroleum operations in Niger-Delta Nigeria was investigated. For the study, a purposive cum random sampling technique was deployed among selected petroleum companies operating in Niger-Delta, Nigeria. A population of 261 of asset integrity engineers/operators, process safety experts, production safety professionals in the petroleum industry in the Niger Delta were sampled using survey questionnaires. Descriptive and inferential statistics (analysis of variance) were used for data analysis. Overall, the study established that process safety cumulative risk assessment has a significant influence in major accident prevention in petroleum operations in Niger-Delta, Nigeria. The study identified seven influencing factors that need to be considered by petroleum industries in Niger-Delta Nigeria, in assessing process safety cumulative risk: (a) preventive and corrective maintenance deviations (agreed by 100% of the respondents), (b) temporary changes (agreed by 98% of the respondents), (c) inhibits/overrides (agreed by 96% of the respondents. Also (d) 97% accounted for downgraded integrity items and (e) Original Research Article