Outcomes of pregnancies using donor sperm compared with those using partner sperm: systematic review and meta-analysis Christopher P. Allen 1, *, Nicola Marconi 1 , David J. McLernon 2 , Sohinee Bhattacharya 2 , and Abha Maheshwari 3 1 Aberdeen Fertility Centre, University of Aberdeen, Aberdeen AB25 2ZL, UK 2 Institute of Applied Health Sciences, University of Aberdeen, Aberdeen AB25 2ZL, UK 3 Aberdeen Fertility Centre, Aberdeen Maternity Hospital, Aberdeen AB25 2ZL, UK *Correspondence address. Aberdeen Fertility Centre, University of Aberdeen, Aberdeen Maternity Hospital, Cornhill Road, Aberdeen AB25 2ZL, UK. E-mail: christopher.allen@abdn.ac.uk https://orcid.org/0000-0003-4161-4837 Submitted on October 17, 2019; resubmitted on May 25, 2020; editorial decision on July 7, 2020 TABLE OF CONTENTS ................................................................................................................................ • Introduction • Methods Search strategy Inclusion and exclusion criteria Outcomes Data collection and analysis Assessment of quality and sensitivity analysis • Results Description of included studies Meta-analyses: early pregnancy outcomes Meta-analyses: obstetric outcomes Meta-analyses: perinatal outcomes • Discussion Main findings Interpretation of findings Strengths Weaknesses Comparison with other studies Implications for clinical practice Implications for future research • Conclusions BACKGROUND: Registry data from the Human Fertilisation and Embryology Authority (HFEA) show an increase of 40% in IUI and 377% in IVF cases using donor sperm between 2006 and 2016. OBJECTIVE AND RATIONALE: The objective of this study was to establish whether pregnancies conceived using donor sperm are at higher risk of obstetric and perinatal complications than those conceived with partner sperm. As more treatments are being carried out VC The Author(s) 2020. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: journals.permissions@oup.com Human Reproduction Update, Vol.27, No.1, pp. 190–211, 2021 Advance Access Publication on October 15, 2020 doi:10.1093/humupd/dmaa030 Downloaded from https://academic.oup.com/humupd/article/27/1/190/5923780 by guest on 17 June 2022