NATIONAL JOURNAL OF MEDICAL RESEARCH print ISSN: 2249 4995│eISSN: 2277 8810 NJMR│Volume 6│Issue 2│Apr – Jun 2016 Page 199 ORIGINAL ARTICLE OUTCOME OF LOW MAINTENANCE DOSE MGSO4 IN ECLAMPSIA PATIENTS OF A TERTIARY CARE HOSPITAL OF GUJARAT, INDIA- A PROSPECTIVE STUDY Krina K Kathawadia 1 , Priyanka C Patel 2 , Smruti B Vaishnav 3 Author’s Affiliations: 1 Tutor; 2 Assistant Professor, Dept. ofObstetrics & Gynaecology, SMIMER Surat; 3 Professor, Dept. ofObstetrics & Gynaecology, P.S.M.C. Karamsad, Gujarat Correspondence: Dr Krina K Kathawadia E-mail: krinakathawadia@gmail.com ABSTRACT Background: Eclamptic convulsions are life-threatening emergencies and require proper treatment to de- crease maternal morbidity and mortality. Amongst the principles of management of eclampsia, the first and foremost is the control of convulsions. In the last decade researchers in developing countries (like India) are constantly striving to steadily decrease the doses of MgSo4 regimes in view of decrease the toxicity of MgSo4 therapy. Methodology: Present study was a prospective interventional study and hdsanalysed all antenatal, intranatal and postnatal cases diagnosed as eclampsia and admitted to Obstetric ward, HDU, ICU (medical and surgi- cal), IMC of Shree Krishna Hospital and Pramukhswami Medical college, Karamsad. All patients of Eclamp- sia admitted in the hospital during the study period were included in the study. Patients fulfilling the inclusion criteria, MgSo4 4gm was administered slowly intravenously over 10-15 minutes as loading dose and mainte- nance dose 0.5g/hr continue up to 24 hrs of delivery or 24hrs after convulsions whichever was later. Those patient were developed recurrent convulsion, they were given 2g MgSo4i.v. stat and maintenance dose was converted in standard dose 1g/hr. Results: In the present study we could achieve the average serum magnesium level around 3.3-3.4 mEq/L. These were below therapeutic range for eclampsia but within the range of normal blood level. Even serum magnesium level in subtherapeutic range, 89.2%patients had not developed recurrent convulsions. 33(71.73%) patients delivered Vaginally and 13(28.26%) were delivered by LSCS. Most common indicationsfor LSCS were fetal distress in 1 st stage of labour followed by severe oligohydroamniosis and failure of induction of la- bour. Conclusion: Low maintenance dose of magnesium sulphate therapy is effective for controlling convulsion in cases of eclampsia. The toxicity is reduced to nil. There was no maternal complication due to recurrent con- vulsions because patient was under close monitoring and immediately the stepping up of dose was enough. Keywords: Eclampsia, MgSo4, Stillbirth, LSCS INTRODUCTION Hypertensive disorders of pregnancy are unpredicta- ble Multiorgan disorder unique to human pregnancy. Pregnancy Induced Hypertension has been a recog- nized pathological entity since the time of Hippocra- tes and ancient Greeks complicating 5-20% pregnan- cies. Convulsions in preeclampsia that cannot be attribut- ed to any other factor defined as Eclampsia. Hyper- tensive disorders are important cause of maternal and fetal morbidity and mortality. Approximately 1,00,000 women die worldwide annually because of eclampsia, A majority of these maternal deaths occur in low-income countries where the quality of mater- nity care is often inadequate. 1 Eclamptic convulsions are life-threatening emergen- cies and require proper treatment to decrease mater- nal morbidity and mortality. Amongst the principles of management of eclampsia, the first and foremost is the control of convulsions. Implementation of MgSo4 would be strengthened if guidelines and recommendations for practice could be based on reliable evidence about the comparative effects of alternative regimens. Regimens for admin- istration of MgSo4 have evolved over the years, but have not been formally evaluated. 2 It is therefore rel-