Malang Respiratory Journal Vol 06(01) page 17 Successful Autologous Blood Patch Pleurodesis: A Safe and Useful Treatment for Persistent Pneumothorax in For- mer Pulmonary Tuberculosis and Aspergillosis in Pregnant Women Nori Purnama 1 , Elvando Tunggul Mauliate Simatupang 1 , Zarfiardy Aksa Fauzi 1 , Sri Indah Indriani 1 , Indra Yovi 1 , Hariadi Hatta 2 , Zulmaeta 3 1 Department of Pulmonology, Faculty of Medicine, Universitas Riau/Arifin Achmad General Hospital, Pekanbaru –Indonesia 2 Department of Thoracic Cardiovascular Surgery, Faculty of Medicine, Universitas Riau/Arifin Achmad General Hospital, Pekanbaru – Indonesia 3 Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Riau/Arifin Achmad General Hospital, Pek- anbaru – Indonesia Abstract Introduction: Autologous Blood Patch Pleurodesis (ABPP) is one of the treatment options for per- sistent pleural air leaks especially in patients who are not suitable for surgical intervention. Persis- tence pneumothorax is defined as pneumothorax of more than five days duration. It is associated with increased morbidity and cost of care. The most widely accepted treatment for it is pleurodesis. Several types of pleurodesis have been proposed, including surgical approaches and the instillation of different chemicals in the intrapleural space. ABPP has proven to be a simple, inexpensive, effica- cious and safe method. Use of ABPP is currently rarely and uncommonly used, but it provides bene- fits especially in special conditions with easier, cheaper, and quite effective procedures. Case Report: A female 35-year-old pregnant women patients with Former Tuberculosis (FTB) come with complaints breathlessness and chest pain worsening since 3 days before admitted to our hospital. Discussion: Chest radiography showed Spontaneous Pneumothorax with GeneXpert (GE) sputum Mtb Not Detected but there is Aspergillosis from Fungal Culture. Water Sealed Drainage (WSD) was inserted in right pleural for almost 1 month and this patient discharge with pneumostat. One month after that she come again with Persistence Pneumothotax, so that we do the pleurodesis with Blood Patch and get the improvement from clinical status. Antifungals are continued for an initial 4-6 weeks while an outpatient evaluation is conducted. Conclusion: ABPP is a safe, inexpensive and efficacious treatment for persistent pleural air leak. Administration of ABPP may be considered for patients with Persistent Pneumothorax. Keywords: Autologous Blood Patch Pleurodesis, Aspergillosis, Former Tuberculosis Received: 20 November 2023 Reviewed: 15 December 2023 Accepted: 1 January 2023 MRJ 2024; 6(1); 17 – 26 * Corresponding author: Nori Purnama (noripurnama@yahoo.com) Department of Pulmonology, Faculty of Medicine, Riau University/Arifin Achmad General Hospital, Pekanbaru –Indonesia