Clinical Study Spectral Domain Optical Coherence Tomography Assessment of Macular and Optic Nerve Alterations in Patients with Glaucoma and Correlation with Visual Field Index Alessio Martucci , 1 Nicola Toschi , 2,3,4 Massimo Cesareo, 1 Clarissa Giannini, 1 Giulio Pocobelli, 1 Francesco Garaci , 2 Raffaele Mancino, 1 and Carlo Nucci 1 1 Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy 2 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy 3 Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA 4 Harvard Medical School, Boston, MA, USA Correspondence should be addressed to Carlo Nucci; nucci@med.uniroma2.it Received 4 July 2018; Accepted 3 September 2018; Published 8 October 2018 Academic Editor: Angelo Balestrazzi Copyright © 2018 Alessio Martucci et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. To evaluate the sectorial thickness of single retinal layers and optic nerve using spectral domain optic coherence tomography (SD-OCT) and highlight the parameters with the best diagnostic accuracy in distinguishing between normal and glaucoma subjects at different stages of the disease. Material and Methods. For this cross-sectional study, 25 glaucomatous (49 eyes) and 18 age-matched healthy subjects (35 eyes) underwent a complete ophthalmologic examination including visual field testing. Sectorial thickness values of each retinal layer and of the optic nerve were measured using SD-OCT Glaucoma Module Premium Edition (GMPE) software. Each parameter was compared between the groups, and the layers and sectors with the best area under the receiver operating characteristic curve (AUC) were identified. Correlation of visual field index with the most relevant structural parameters was also evaluated. Results and Discussion. All subjects were grouped according to stage as follows: Controls (CTRL); Early Stage Group (EG) (Stage 1 + Stage 2); Advanced Stage Group (AG) (Stage 3 + Stage 4 + Stage 5). mGCL TI, mGCL TO, mIPL TO, mean mGCL, cpRNFLt NS, and cpRNFLt TI showed the best results in terms of AUC according classification proposed by Swets (0.9 < AUC < 1.0). ese parameters also showed significantly different values among group when CTRL vs EG, CTRL vs AG, and EG vs AG were compared. SD-OCT examination showed significant sectorial thickness differences in most of the macular layers when glaucomatous patients at different stages of the disease were compared each other and to the controls. 1. Introduction Primary open-angle glaucoma, a leading cause of blindness in the world, is an optic neuropathy characterized by the death of ganglion cells of the retina, which is associated with the loss of axons that make up the optic nerve. ese ultrastructural alterations gradually progress becoming clinically evident as an increased excavation of the optic discandthepresenceofspecificvisualfield(VF)defects[1]. Diagnosing and monitoring disease progression is there- fore essential for the management of patients with glau- coma. Given that a significant structural loss usually precedes detectable function loss [2], technologies and strategies able to quantify glaucomatous changes at an early stage have the potential to impact prognosis and hence influence quality of life [3]. In this context, spectral domain-optical coherence tomography (SD-OCT) pro- vides a tool for macular segmentation and thickness evaluation of individual retinal layers as well as retinal nerve fiber layer thickness (RNFLt) and Bruch’s membrane opening (BMO)-minimum rim width (MRW) assessment. e patented Anatomic Position System (APS) creates an anatomic map of each patient’s eye using the center of the fovea and the center of BMO as landmarks. In turn, this allows accurate localization and hence highly sensitive assessment of structural changes. Hindawi Journal of Ophthalmology Volume 2018, Article ID 6581846, 9 pages https://doi.org/10.1155/2018/6581846