pISSN 1978-2071 | eISSN 2580-5967 Jurnal Ilmiah Kedokteran Wijaya Kusuma 13(1): 63-69, March 2024 63 | Page Register with CC BY NC 4.0 license. Copyright © 2022, the author (s) ARTICLE INFO AUTHOR’S AFFILIATIONS Internal Medicine Department, Faculty of Medicine Sultan Agung Islamic University – Sultan Agung Islamic Teaching Hospital, Semarang Indonesia 1 Research Assistant, Division of Respirology and Critical Illness, Department of Internal Medicine Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jakarta, Indonesia 2 CORRESPONDING AUTHOR Muhammad Rizki Triono Research Assistant Division of Respirology and Critical Illness, Department of Internal Medicine Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo General Hospital, Jakarta, Indonesia E-mail: m.rizkitriono@gmail.com Article history Received 23-01-2024 Revised 26-01-2024 Accepted 22-03-2024 Available online Please cite this article in APA 7 th edition style as: Abduh, M. S., Triono, M. R., Widyastuti, R. (2024). Role of Anemia and Leukocytosis as Severity Predictors of Coronary Artery Disease Stenosis : A Retrospective Cross-sectional Study. Jurnal Ilmiah Kedokteran Wijaya kusuma, 13(1), XX-XXX https://doi.org/10.30742/jikw.v1 3i1.3555 Role of Anemia and Leukocytosis as Severity Predictors of Coronary Artery Disease Stenosis: A Retrospective Cross-sectional Study M Saugi Abduh 1 , Muhammad Rizki Triono 2* , Retno Widyastuti 1 Abstract Background: Anemia and leukocytosis were found to be associated with conditions that higher the risk for the formation of atherosclerotic plaque which will develop into cardiovascular disease. Basic laboratory parameters such as anemia and leukocytosis are not routinely used to assess Coronary Artery Disease (CAD) severity based on its stenosis. This study aimed to analyze the role of simple laboratory examiantion anemia and leukocytosis as predictors of the severity of stenosis in CAD. Methods: Cross-sectional approach was used in this study. Secondary data on CAD patients treated at Sultan Agung Islamic Hospital Semarang in 2022 were analyzed. Anemia and leukocytosis are the main risk factors analyzed in this study. Other risk factors such as gender, age, smoking status, hypertension and diabetes mellitus (DM) were also included in the analysis of this study. We performed bivariate analysis and multivariate analysis to see the relationship between these risk factors and the CAD stenosis severity. Results: Bivariate analysis with chi-square showed that anemia had a significant relationship with CAD severity (P<0.05). Multivariate analysis between anemia and smoking status reported that anemia was the most significant risk factor for the CAD stenosis severity (P<0.05). Conclusion: No association found between leukocytosis and CAD severity. Keywords: anemia, severity, coronary artery disease, immunity, leukocytosis, stenosis Original Research Article INTRODUCTION Coronary Artery Disease (CAD) is a condition of an imbalance between the need for blood and oxygen delivered to the myocardium, resulting in a lack of supply to the myocardium (Cassar et al., 2009). This imbalance is caused by plaque blocking blood flow in the coronary arteries, which ultimately causes dysregulation of the supply and demand of oxygen throughout the body (Shahjehan, 2022). This