* Corresponding author: P. L. Harale Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0. Synthesis of 3-(substitutedthiocarbamide)-aniline derivatives from di-tert-butyl dicarbonate (BoC) protected 3-chloroaniline P. L. Harale 1, 2, * , M. E. Shelke 1 , D.T. Tayade 1 and A. R. Kurhe 2 1 Department of Chemistry, Govt. Vidarbha Institute of Science and Humanity, Amaravati, India. 2 Research Centre and Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar, India. GSC Biological and Pharmaceutical Sciences, 2024, 28(03), 046–052 Publication history: Received on 18 July 2024; revised on 30 August 2024; accepted on 02 September 2024 Article DOI: https://doi.org/10.30574/gscbps.2024.28.3.0313 Abstract Synthesis of substituted thiocarbamide derivatives is important in the fields of medicinal, agricultural, chemical, and pharmaceutical. Thiocarbamides are commonly utilized as starting materials for several organic synthetic processes and have been studied in search for easy and effective methods of chemical synthesis. In the existing research work, 3- chloroaniline was protected by a di-tert-butyl dicarbonate (BoC) protecting agent. Substituted thiocarbamide derivatives were synthesized using condensation of various substituted thioureas with amino group-protected 3- chloroaniline. The structures of all compounds of 3(substitutedthiocarbamido)-aniline were characterized by 1 H-NMR, 13 C-NMR, FT-IR, LCMS and CHNS elemental analysis. Keywords: 3-chloroaniline; Di-tert-butyldicarbonate; Thiocarbamide derivatives; Protecting agent Graphical Abstract 1. Introduction Thiourea, often known as thiocarbamide, is a chemical compound having the formula SC(NH2)2 with a molecular weight of 76.12 g/mol [1,5]. The class of chemicals known as substituted thiocarbamide has the generic formula (R1R2N) (R3R4N) CS [6,8]. Thiocarbamides are soluble in organic solvents that are polar protic and aprotic, such as acetone and dimethyl sulfoxide. It is also soluble in water, but insoluble in non-polar solvents. Because of the difference in electronegativity between sulfur and nitrogen, the chemical properties of thiourea change significantly. Thiocarbamides show higher acidity and are stronger hydrogen bond donors [9, 12]. Being able to be involved with bonding with hydrogen, which is able to be further adjusted by proper nitrogen atom substitution, is critical for a wide range of uses