Does the Modified Glasgow Prognostic Score be a Predictive Parameter for Right Ventricular Systolic Dysfunction in Patients with Acute Decompensated Heart Failure? Address for correspondence: Mustafa Kaplangoray, MD. Department of Cardiology, Bilecik Şeyh Edebali University, Bilecik, Türkiye Phone: +90 532 394 56 38 E-mail: mkaplangoray@gmail.com Submitted Date: June 26, 2023 Accepted Date: September 14, 2023 Available Online Date: September 19, 2023 © Copyright 2023 by Eurasian Journal of Medicine and Investigation - Available online at www.ejmi.org OPEN ACCESS This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. A ll forms of heart failure (HF) are among the major causes of cardiovascular-related mortality and morbidity.End- stage heart failure still has a high morbidity and mortality rate despite advances in its treatment. [1] In contrast to what was believed in the past, recent studies have shown that the right ventricle (RV) is more than a passive conduit and that optimal function of the RV plays an important role in global cardiac function.It is also known that right heart ven- tricular systolic dysfunction (RHF) is an independent factor for mortality in patients with HF. [2] Although many factors are involved in the etiology of RHF, the major cause is left ventricular (LV) dysfunction. Edema in the intestinal region which develops secondary to RHF and venous congestion is known to play a role in malnutrition in these patients. [3] Objectives: Right ventricular sistolic dysfunction (RHF) is associated with a poor prognosis in paients with acute de- compensated heart failure (ADHF), regardless of the degree of left ventricular (LV) dysfunction. As previously shown, cachexia in heart failure is associated with right ventricular (RV) dysfunction rather than LV impairment. Modified Glasgow prognostic score (mGPS), which is calculated based on serum albumin (SA) and C-reactive protein (CRP) levels, is associated with inflammatory and nutritional status. Aims of this study was to investigate the relationship between mGPS and RV functions in patients with ADHF. Methods: We prospectively enrolled 122 ADHF consecutive patients with reduced LV ejection fraction (LVEF <%35). RHF was determined according to RV fractional area change (RV FAC). Patients with RVFAC <35 % were considered as biventricular heart failure (BHF) and those with RVFAC ≥35% were considered as isolated left heart failure (isolated- LHF). mGPS was scored as 0, 1 or 2 according to CRP and SA levels. Results: Compared to isolated-LHF patients, mGPS, B-type natriuretic peptide (BNP), CRP, systolic pulmonary artery pressure (SPAP), mitral E/Em were higher, while SA, hemoglobin, tricuspid annular plane systolic excursion (TAPSE) and RVFAC were lower in BHF patients (p<0.05). Correlation analysis showed a significantly correlation of mGPS with RHF (r=-0.424, p<0.001). Logistic analysis showed mGPS [OR:1.098 (1.027-1.179), p=0.012] was an independent predictive factor for RHF. Conclusion: mGPS is an important independent predictor of RV dysfunction in patients with ADHF. Keywords: Right ventricular systolic dysfunction, heart failure, modified Glasgow prognostic score, echocardiograpy Mustafa Kaplangoray, 1 Kenan Toprak 2 1 Department of Cardiology, Bilecik Şeyh Edebali University, Bilecik, Türkiye 2 Department of Cardiology, Harran University Faculty of Medicine, Şanlıurfa, Türkiye Abstract DOI: 10.14744/ejmi.2023.23563 EJMI 2023;7(3):303–308 Research Article Cite This Article: Kaplangoray M, Toprak K. Does the Modified Glasgow Prognostic Score be a Predictive Parameter for Right Ventricular Systolic Dysfunction in Patients with Acute Decompensated Heart Failure? EJMI 2023;7(3):303–308.