1 Family History Assessment Significantly Enhances Delivery of Precision Medicine in the Genomics Era Yasmin Bylstra FHGSA (GenCouns) 1 , Weng Khong Lim PhD 1,2,3 , Sylvia Kam MSc 1,13 , Koei Wan Tham BSc 1,4 , R. Ryanne Wu MD 5,6 , Jing Xian Teo BSc 1 , Sonia Davila PhD 1,3,7 , Jyn Ling Kuan BSc 1 , Sock Hoai Chan PhD 8 , Nicolas Bertin PhD 9 , ChengXi Yang BSc 10 , Steve Rozen PhD 1,2 , Bin Tean The MD, PhD 1,11 , Khung Keong Yeo MBBS 7,12 , Stuart Alexander Cook MBBS, PhD 1,7,12 , Lori A. Orlando MD 5 , Saumya Shekhar Jamuar MBBS 1,3,13,14 , Geoffrey S. Ginsburg MD, PhD 5 , Patrick Tan MD, PhD 1,2,15 1 Singhealth Duke-NUS Institute of Precision Medicine, Singapore 2 Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 3 SingHealth Duke-NUS Genomic Medicine Center, Singapore 4 Department of Physiology, National University of Singapore 5 Center for Applied Genomics and Precision Medicine, Department of Medicine, Duke University School of Medicine, Durham, USA 6 Durham Veteran Affairs Cooperative Studies Program Epidemiology Center, Durham, USA 7 Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 8 Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore 9 Centre for Big Data and Integrative Genomics, Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 10 National Heart Research Institute Singapore, National Heart Centre Singapore 11 National Cancer Centre Singapore, Singapore 12 Department of Cardiology, National Heart Centre Singapore, Singapore 13 Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore 14 Paediatric Academic Clinical Programme, Duke-NUS Medical School, Singapore 15 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore . CC-BY-NC-ND 4.0 International license preprint (which was not certified by peer review) is the author/funder. It is made available under a The copyright holder for this this version posted January 30, 2020. . https://doi.org/10.1101/2020.01.29.926139 doi: bioRxiv preprint