4602 Indian Journal of Forensic Medicine & Toxicology, April-June 2021, Vol. 15, No. 2 The Effect of Spiritual Qur’anic Emotional Freedom Technique (SQEFT) Therapy on Reducing Anxiety Value and Blood Cortisol Levels in NAPZA (Narcotics, Psychotropic, Other Addictive Substances) Residents Asmawati, Veny Hadju 1 , Alimin Maidin 2 , Andi Ummu Salmah 2 , Ridwan Amiruddin 2 , Aminuddin Syam 2 , Muh.Tahir Abdullah 2 1 Research Scholar, Department of Public Health Doctoral Education Program, 2 Lecturer of Public Health Doctoral Education Program, Department of medical Science, Faculty of Public Health, Hasanuddin University, Makassar Abstract Introduction: The patients in general and, in particular, the patients of drug/NAPZA (Narcotics, Psychotropic, and Other Addictive Substances) residents seek spiritual support during illness and undergo rehabilitation. Both religion and spirituality are related to positive coping mechanisms (psychological) and exercise (physical). NAPZA (drug) residents undergoing rehabilitation experience anxiety, including moderate anxiety and severe anxiety, which can adversely affect physical and mental disorders. This research aims to determine the effect of Spiritual Qur’anic Emotional Freedom Technique (SQEFT) therapy on reducing anxiety values and blood cortisol levels in NAPZA residents. Method: The experiment was used with a pre-post control group design, and purposive sampling was as the sampling technique. This research was conducted at Mandatory Report Recipient Institution (IPWL) Pelita Jiwa Insani Foundation in Padang, consisting of 44 respondents who were divided into two groups, namely the experimental group (n=24) and the control group (n=20). Data were collected using the Hamilton Rating Scale questionnaire to determine the reduction in anxiety values and venous blood sampling for measuring blood cortisol levels. Data were analyzed using the Wilcoxon signed-rank test and the Mann-Whitney test. Results and Analysis: the results of the research on the anxiety variable obtained p-value = 0.004 (p<0.05), which means that there is a significant difference given the Spiritual Qur’anic Emotional Freedom Technique (SQEFT) therapy in reducing the value of anxiety in NAPZA residents currently undergoing rehabilitation. The cortisol variable results showed p=0.00 (p<0.05), so it can be interpreted that there is a significant difference in the difference value of cortisol in reducing blood cortisol levels in NAPZA residents who are undergoing rehabilitation. Discussion and Conclusion: There is a significant effect of giving Spiritual Qur’anic Emotional Freedom Technique (SQEFT) therapy on reducing anxiety values and blood cortisol levels in NAPZA residents. Keywords: NAPZA, SQEFT therapy, anxiety, blood cortisol levels. Background NAPZA (Narcotics, Psychotropic, and Other Addictive Substances) Residents need family support and motivation because they experience stressful conditions and are not prepared to face reality. Confused thoughts will lead to mood swings, anxiety, depression, decreased immunity, and more severe signs and symptoms. At present, in addition to pharmacological treatment, non- pharmacological treatment is also carried out. Therapy is currently in demand by patients in general and in particular NAPZA residents. Besides having no side effects, the cost is relatively cheap, easy, affordable, and can be applied to everyday life without others’ help. One of the efforts to prevent the problems experienced by NAPZA addicts is by conducting Spiritual Qur’anic Emotional Freedom Technique (SQEFT) therapy. SQEFT is a combination development of ruqyah syar’i