16 – 19 September 2017, Vienna, Austria Poster discussion hub abstracts
Methods: From a group of consecutive patients suspected for
ovarian cancer (OC) (symptoms, ascites, elevated cancer antigen
(CA) 125) and who underwent laparotomy, 14 had PPC
(tumour disseminated on the peritoneum without or with only
minimal ovaries involvement). Before surgery all patient underwent
standardised transvaginal and abdominal ultrasound examination
with predefined definitions (images and videos stored) so to calculate
RMI, LR2, ADNEX, SR. A subjective assessment was to discriminate
between malignant and benign disease in a 6 point score.
Results: High RMI was assessed in all cases. Tumours were
classified as malignant (n=3) or inconclusive (n=11) with
IOTA-SR. Median value of LR2 was 75.1% (range: 34.7-94.9).
Median values of ADNEX model calculations were as follows:
risk of malignancy-98.6% (range: 85.6-99.9), risk of stage
II-IV OC-89.9%, risk of stage I OC -1.1%, risk of borderline
tumour-0.45%, risk of metastatic cancer-7.4%. Once ADNEX
model was calculated without CA125, in all cases with ascites the
risk of malignancy was still over 91%, while in patients without
ascites (n=3) this value was 58-63%. In subjective assessment
all patients were suspected for malignancy. There were no pelvic
tumours with locules, nor with papillations. Ascites and metastatic
tumours in abdominal cavity were detected in 11 and 12 patients
respectively. Median ultrasound diameter of ovaries or ovarian
involvement was 34mm. Median concentration of CA125 was
928 U/ml (98-7000).
Conclusions: In cases with PPC, the RMI, ADNEX model and
subjective ultrasound assessment can predict malignancy with a very
high accuracy. Evaluation of CA125 should be considered, both as
a single diagnostic measure and a part of ADNEX model. IOTA-SR
has limited value in diagnosing PPC.
P30.03
Imaging in gynecological disease: clinical and ultrasound
features of ovarian endometrioid carcinoma
F. Moro
8
, G. Magoga
8
, T. Pasciuto
8
, A. Di Legge
8
,
M. Moruzzi
8
, D. Fischerov ´ a
9
, L. Savelli
7
, A. Czekierdowski
6
,
D. Timmerman
5
, W. Froyman
5
, D. Verri
10
, E. Epstein
2
,
V. Chiappa
3
, S. Guerriero
4
, L. Valentin
1
, A.C. Testa
8
1
Sk˚ ane University Hospital Malm ¨ o, Lund University, Malmo,
Sweden;
2
Department of Clinical Science and Education,
S¨ odersjukhuset and Department of Women’s and Children’s
Health Karolinska Institutet, Stockholm, Sweden;
3
Gynecologic Oncology, National Cancer Institute of Milan,
Milan, Italy;
4
Department of Obstetrics and Gynecology,
University of Cagliari, Cagliari, Italy;
5
Department of
Development and Regeneration, KU Leuven; Department of
Obstetrics and Gynecology, University Hospitals Leuven,
Leuven, Belgium;
6
First Departmentof Gynecological
Oncology, Medical University of Lublin, Lublin, Poland;
7
Obstetrics and Gynecology, Gynecologic and Early
Pregnancy Ultrasound Unit, Bologna, Italy;
8
Obstetrics and
Gynecology, Catholic University of the Sacred Heart, Rome,
Italy;
9
Gynecological Oncology Centre, Department of
Obstetrics and Gynecology, First Faculty of Medicine,
Charles University, Prague, Czech Republic;
10
Department of
Obstetrics and Gynecology, University of Milan-Bicocca, San
Gerardo Hospital, Monza, Italy
Objectives: To describe clinical and ultrasound features of ovarian
endometrioid carcinoma.
Methods: Patients with a histological diagnosis of ovarian
endometrioid carcinoma, who had undergone preoperative ultra-
sound, were retrospectively identified from 10 ultrasound cen-
tres. The masses were described using the terms of the
IOTA group.
Results: 192 patients with a diagnosis of endometrioid car-
cinoma were identified. Median age of the patients was 56
(range,19-88) years. Most of the staged cases were FIGO Stage
I (n=113/191,59.2%) and the vast majority of the tumours having
an available grading were of grading 1 or 2 (n=124/172,72%).
Forty (20.8%) cases were associated with endometriosis. On ultra-
sound, 2 (1%) carcinomas were unilocular, 2 (1%) multilocular,
34 (17.7%) unilocular-solid, 89 (46.4%) multilocular-solid and
65 (33.9%) solid masses. The median of the largest diameter of
the lesion was 104 (range 20-300) mm. Papillary projections were
present in 61 (31.8%) masses. The echogenicity of cyst fluid was
anechoic in 27 (14.1%) cases, low level in 72 (37.5%), ground glass
in 17 (8.9%), hemorrhagic in 2 (1%) and mixed in 10 (5.2%),
whereas 64 (33.3%) cases had no cyst fluid. 149 cases (77.6%)
were unilateral.
Conclusions: Primary ovarian endometrioid cancer was most
commonly found between the fifth and sixth decade, associated
with endometriosis in one fourth of patients. Endometrioid cancers
were usually low risk ovarian cancers presenting in an early stage as
large, unilateral, multilocular-solid tumours or solid mass.
Supporting information can be found in the online
version of this abstract
P30.04
Does rectal enema improve the accuracy of ultrasonography
in predicting rectosigmoid infiltration in patients with ovarian
cancer?
S. Ferrero
1,2
, C. Bondi
1
, F. Laraud
1
, F. Barra
1
, C. Scala
1,2
,
P.L. Venturini
1
, V. Vellone
3
1
Academic Unit of Obstetrics and Gynecology, IRCCS AOU
San Martino-IST, University of Genova, Genoa, Italy;
2
Piazza della Vittoria 14 SRL, Genoa, Italy;
3
Department of
Surgical and Diagnostic Sciences, IRCCS AOU San
Martino-IST, University of Genova, Genoa, Italy
Objectives: To investigate the accuracy of ultrasound with and
without rectal enema in predicting rectosigmoid infiltration in
patients with epithelial ovarian cancer (OC).
Methods: This prospective study included 52 patients with epithelial
OC who underwent primary surgery. Carcinomatosis was defined
as a nodular or sheet-like hypoechoic structure, vascularised,
attached to the peritoneum of the rectosigmoid or invading
into the muscularis propria. Both superficial carcinomatosis and
nodules invading the bowel wall were considered rectosigmoid
infiltration. The depth of Infiltration of the intestinal wall was
assessed. One ultrasonographer performed the exam without rectal
enema. Another ultrasonographer blinded to the findings of the
first investigator performed the scan only after distention of the
rectosigmoid wall (200-350 ml of saline solution slowly injected
inside the rectosigmoid).
Results: Surgery and histology revealed rectosigmoid infiltration in
24 patients (46.2%). The diagnostic performance of ultrasonography
without rectal enema was sensitivity 75.0%, specificity 92.9%,
positive likelihood ratio 10.50, negative likelihood ratio 0.27,
positive predictive value 90.0%, negative predictive value 81.3%.
The diagnostic performance of ultrasonography with rectal enema
was sensitivity 87.5%, specificity 96.4%, positive likelihood ratio
24.50, negative likelihood ratio 0.13, positive predictive value
95.45%, negative predictive value 90.0%. The Mc Nemar’s
test revealed there was no significant difference between the
two techniques in diagnosing rectosigmoid infiltration (p=0.134).
Similarly, rectal enema did not increase the accuracy of ultrasound
in discriminating superficial carcinomatosis or infiltration reaching
at least the muscularis propria (p=0.578). The patients reported
that ultrasonography without enema was less painful that
ultrasonography with enema (p<0.001).
© The Authors 2017
© Ultrasound in Obstetrics & Gynecology 2017; 50 (Suppl. 1): 154–256. 253