Volume 7 | Issue 1 | 1 of 4 Microbiol Infect Dis, 2023 Mutation in the Rifampicin Resistance Region in Mycobacterium Tuberculosis in Guinea 1 National Reference Laboratory for Mycobacteria Ignace Deen National Hospital, Conakry, Republic of Guinea. 2 National Public Health Laboratory, Conakry, Republic of Guinea. 3 Department of Pharmaceutical and Biological Sciences, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Republic of Guinea. 4 Biomedical laboratory of the China-Guinea Friendship Hospital, Kipé, City of Doctors, Commune Ratoma 30 BP: 710 Conakry, Republic of Guinea. 5 Department of Medicine, Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Republic of Guinea. 6 Pneumophthisiology Department, Ignace Deen National Hospital, Conakry, Republic of Guinea. Moussa Condé 1 , Alimou Camara 2,3 , Abdoulaye Makanéra 4,5* , F. Nzabintwaly 6 , Lansana Mady Camara 5,6 and Fodé Bangaly Magassouba 3 Citation: Condé M, Camara A, Makanéra A, et al. Mutation in the Rifampicin Resistance Region in Mycobacterium Tuberculosis in Guinea. Microbiol Infect Dis. 2023; 7(1): 1-4. Research Article ABSTRACT Introduction: In recent years, strains of Mycobacterium tuberculosis resistant to rifampicin have become frequently encountered in Guinea. This fact is regularly notified since the installation of GeneXpert automatons in hospital structures in Conakry and in the capital of the administrative regions as well as the various prefectures of Guinea. Objective: The aim of this present study was to determine the rifampicin resistance profiles of Mycobacterium tuberculosis strains at the Pneumophtisiology Department of the Ignace Deen National Hospital of Conakry. Methods: We conducted a retrospective and analytical study lasting 22 months from January 2017 to June 2018 then from April to July 2019 on the files of patients received at the National Reference Laboratory for Mycobacteria of the Ignace Deen National Hospital of Conakry for examinations of samples on the GeneXpert. Results: In 325 cases of rifampicin resistance, we found mutations associated with region E (42.15%), region D (35.38%), region B (15.08%), region A (1.53%) and that of C (0.92%). We also observed multiple mutations A-B (0.92%), A-D (3.69%), D-E (0.30%). Conclusion: The proportion of E probes was the highest followed by D probes then B probes (512-518). We encountered multiple mutations, like A-B, A-D, D-E. * Correspondence: Abdoulaye MAKANERA, Laboratoire biomédical de l’Hôpital de l’Amitié Sino-Guinéenne, Kipé, Cité des Médecins, Commune Ratoma 030 BP : 710 Conakry, République de Guinée, Tel. 00224 664 309523/ 00224 621015770 Received: 16 Dec 2022; Accepted: 15 Jan 2023; Published: 20 Jan 2023 Microbiology & Infectious Diseases ISSN 2639-9458