Toward the Optimization of a Plant-Based Oral Vaccine Against Cysticercosis Edda Sciutto, Marisela Hernández, Jacquelynne Cervantes-Torres, Elizabeth Monreal-Escalante, Omayra Bolaños-Martínez, Juan Francisco Rodríguez, Gladis Fragoso and Sergio Rosales-Mendoza Abstract It is recognized that an effective, low-cost oral vaccine may effectively contribute to prevent Taenia solium cysticercosis; plant-based vaccines, on the other hand, can make this goal feasible. Plants are optimal platforms for the massive production of oral vaccines. In this chapter, advances toward the development of oral plant-based vaccine against cysticercosis are reviewed. Keywords Oral vaccine Á Transgenic plant Á Transplastomic plant Carica papaya Á Daucus carota Á Nicotiana tabacum Á Taenia solium 1 Introduction 1.1 Relevance of Cysticercosis Taeniasis/cysticercosis is a parasitic infection caused by Taenia solium. It is prevalent in areas with low socioeconomic and sanitary standards in developing E. Sciutto Á M. Hernández Á J. Cervantes-Torres Á E. Monreal-Escalante Á O. Bolaños-Martínez J. F. Rodríguez Á G. Fragoso Dpto. Inmunología. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Circuito Escolar. Ciudad Universitaria, 04510 México, CDMX, Mexico e-mail: edda@servidor.unam.mx S. Rosales-Mendoza (&) Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, 78210 San Luis Potosí, SLP, Mexico e-mail: rosales.s@fcq.uaslp.mx S. Rosales-Mendoza Sección de Biotecnología, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, Lomas 2ª. Sección, 78210 San Luis Potosí, Mexico © Springer International Publishing AG, part of Springer Nature 2018 J. MacDonald (ed.), Prospects of Plant-Based Vaccines in Veterinary Medicine, https://doi.org/10.1007/978-3-319-90137-4_10 227