This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/bdd.2107 This article is protected by copyright. All rights reserved. Full title: Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software Short title: Prediction of CYP450-mediated DDIs by Simcyp Authors: Niloufar Marsousi 1,2 , Jules A. Desmeules 1,2,3,4 , Serge Rudaz 2,3 , Youssef Daali 1,2,3,4 Acknowledgments The authors wish to thank Simcyp® Limited., a Certara Company, for the academic license of the Simcyp® Population-based Simulator, and providing user support. Conflict of interest The authors report no conflict of interest and no specific funding was acquired for the preparation of this manuscript. _________________________________________________________________________ 1 Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Switzerland 2 School of pharmaceutical sciences, Geneva and Lausanne Universities, Switzerland 3 Swiss Center for Applied Human Toxicology (SCAHT), University of Basel, Switzerland 4 Faculty of medicine, Geneva University, Switzerland Corresponding author: Division of Clinical Pharmacology and Toxicology Geneva University Hospitals Rue Gabrielle Perret-Gentil 4, 1211 Geneva, Switzerland Email: Youssef.daali@hcuge.ch Tel: (+41) 22 379 54 30