S62 Abstracts of 4th International Congress of WASM & 5th Conference of CSS / Sleep Medicine 12, Suppl. 1 (2011) S1–S130 T-D-014 HEALTH ANXIETY AMONG POOR SLEEPERS Angela Lachowski, Taryn Moss, Colleen Carney, Andrea Harris, Stacey Hart, Jenna Belanger. Ryerson University, Canada Introduction and Objectives: There is evidence to support an MMPI som- atization profile in those with insomnia (e.g., Kales et al., 1976; Levin et al., 1984). Indeed, the belief that insomnia will have serious adverse consequences on one’s health discriminates good sleepers from those with clinical insomnia, and modifying this belief with Cognitive Behaviour Ther- apy (CBT-I) is associated with improvement of wakefulness after sleep onset (Carney & Edinger, 2006). It is possible that some people with insomnia have significant levels of health-related anxiety, but this has yet to be examined. This study investigated the relationship between sleep and health anxiety by comparing good and poor sleepers on health anxiety. Materials and Methods: Participants (N = 119, 85.7% females; Mean age = 20.39 years old) were undergraduate students recruited from Ryerson Uni- versity. Participants completed a battery of online questionnaires including the Short Health Anxiety Index (HAI; Salkovskis et al., 2002) to assess for health anxiety and the Insomnia Severity Index (ISI; Morin, Vallières, & Ivers, 2007) to assess for insomnia symptoms. Participants who scored ≤7 on the ISI were classified as good sleepers, and participants who scored ≥8 were classified as poor sleepers. Results: Of the sample, 55% of participants were classified as poor sleepers. Health anxiety scores were found to be significantly higher among poor (M = 17.64, SD = 8.10) versus good sleepers (M = 13.85, SD = 7.50, t(103) = -2.461, p<0.05). Conclusion: These findings suggest that relative to good sleepers, health anxiety is significantly elevated in poor sleepers. Should future investiga- tions of health anxiety in clinical insomnia sufferers replicate this finding, it could lead to possible treatment add-ons to CBT-I. CBT for health anxiety is an empirically supported treatment (Barsky & Ahern, 2004) that may include tools that could be used in CBT-I. T-D-015 IMMUNOLOGIC ALTERATIONS IN INSOMNIA Sayonara Beatriz Ranciaro Fagundes, Derlei João Leite Fagundes, André L.L. Bachi, Lucila Bizari Fernandes Prado, João Eduardo Coin Carvalho, Luciane Bizari Coin Carvalho, Mauro Vaisberg, Gilmar Fernandes Prado. UNIFESP, Brazil Introduction and Objectives: Insomnia is defined as the complaint of not being able to fall asleep or to maintain sleep, and/or nonrestorative sleep, accompanied by impaired daytime functioning on a social, emotional or professional level. Sleep loss has an impact on the expression of cytokines genes. Objectives. The aim of the present study was to investigate whether there is a difference in daytime interleukin-6 (IL-6) and TNF serum excretion in runners with insomnia vs without insomnia. Materials and Methods: We studied IL-6 and TNF in 33 marathon runners participating in the São Paulo Marathon (42.195Km), who finished the race. One runner was excluded and we investigated IL-6 and TNF basal, immediate and post 72h. We compared insomniac vs non insomniac runners. Results: We found 21.21% of runners with insomnia. IL-6 showed elevation in non insomniac (basal = 24.49±40.58; immediate = 124.96±92.907), compared to insomniac immediately after the race (basal = 28.841±31.294; immediate = 71.17±47.598), and all returned to basal levels (72h = 10.57± 18.73 vs 72h = 19.614±39.461). TNF showed negative association with insomnia: insomniac runners: basal = 6.54±4.73; immediate = 10.55±7.36; 72h = 2.87±1.425 and no insomniac: basal = 7.26±13.32; immediate = 36.75±43.55; 72h = 5.69±13.84. Conclusion: Studies suggest that IL-6 is a putative ‘sleep factor’ and its circadian secretion correlates with sleep/sleepiness. Following sleep depri- vation or in disorder of sleep disturbance, e.g. insomnia, IL-6 is elevated during the day. Our study demonstrated that higher systemic inflammation, as demonstrated by serum IL-6 immediately after the race is associated with good sleep. TNF is elevated in disorders associated with excessive daytime sleepiness (EDS) and studies suggest that TNF are a possible mediator of EDS. Our findings confirm this association. Runners may be effective for improving the quality of sleep. Sleep is gradually regarded as a restorative process important for proper immune system functioning. Recognizing the extremely heavy burden of insomnia and related complications in the pop- ulation, more aggressive action to survey patients with sleep disorders and adequate intervention is increasingly important. Acknowledgements: The authors gratefully acknowledge the athletes for their patience as well as Gianni M.S. dos Santos for help with statistic analysis and FAPESP who sponsor these study. T-D-016 INSOMNIA AND COMORBIDITIES IN THE ELDERLY Fernando Andrés-Pretel 1 , Beatriz Navarro 1 , Jesús López-Torres 2 , Ignacio Párraga 2 , Pedro Abizanda Soler 3 , Pedro Sanchez Jurado 3 . 1 Health and Social Care Fundation of Castilla-La Mancha, Spain; 2 Primary Care Head Office of Albacete, Spain; 3 University General Hospital of Albacete, Spain Introduction and Objectives: Insomnia complaints in the elderly are asso- ciated with other health problems, the consumption of medication, poor self-perceived health and a higher use of health care services. The main objective of this study has been to analyze which illnesses are more often associated with insomnia due to a general medical condition (DSM-IV-TR criteria). Materials and Methods: Cross-sectional, observational study performed in the city of Albacete (Spain). Participants were randomly selected from a list of persons over 65 years of age on the register of public health cardholders. The sample size was 926 subjects. Participants were diagnosed through an interview conducted by psychiatrists. They were also questioned about their sociodemographic characteristics and their health problems (ICPC-2) by nurses or psychologists. Results: The mean age was 74.38 years (45.2% men). Health problems more prevalent were those related to the circulatory system (74.0%), endocrine system, metabolism and nutrition (55.7%), locomotive system (34.9%), di- gestive system (11.2%) and respiratory system (10.3%). A prevalence of 7.0% of insomnia due to a general medical condition was observed. Using logistic regression, it was determined that there was a statistically significant associ- ation between the presence of insomnia due to a general medical condition and the following variables: presence of any illness of the locomotive system (OR:1.808; p=0.037), presence of any illness of the male genital system (OR:3.398; p=0.001) and presence of 4 or more health problems (OR:2.009; p=0,000). Of these illnesses, among those who presented insomnia due to a general medical condition, the more prevalent were osteoarthritis (31,75%), signs or symptoms related to the prostate (15,87%), osteoporosis (14,29%), back pain (4,76%) and rheumatoid arthritis (4,76%). Conclusion: Among those people who present with a diagnosis of insomnia due to a general medical condition, the illnesses associated with that diag- nosis are those related with the locomotive system and the male genital system. Acknowledgements: This research has been funded through a grant from the Castilla-La Mancha Health Research Foundation (FISCAM). T-D-017 INSOMNIA AND PERIODIC LIMB MOVEMENTS WITH NO RLS. ACTORS OR BYSTANDERS? Al de Weerd. Sleepcenter SEIN Zwolle, Netherlands Introduction and Objectives: Periodic Limb Movements in Sleep (PLMS) have a prevalence up to 25% of the population, increasing with age. They often occur together with other disorders as Parkinsons disease, renal failure, use of anti-depressants, etc. Eighty percent of patients with Restless Legs Syndrome (RLS) have PLMS. Still, a high percentage of patients with PLMS have no causative or related co-morbidity. In these cases the PLMS are often thought to be just concurrent with another disorder, for which polysomnography (PSG) was performed, for example insomnia. Some stud- ies suggest that PLMS and the accompanying arousals from sleep may cause tiredness and excessive sleep during daytime, which still may introduce clinical significance for these events in the night. The presentation is meant to summarize the ongoing discussion if PLMS have clinical significance in cases with no RLS and if PLMS should be treated as a separate entity, in particular when seen in insomnia patients. Materials and Methods: The literature search will be discussed, but gives no clear answers. There is a tendency that PLMS should be considered as nonspecific events during the night with no need for therapy except for patients with RLS. As a challenge to this theory, patients with insomnia and PLMS but no RLS were treated with dopamine agonists (DA). Results: Recent studies (Ferri et al., de Weerd et al.) suggest that subgroups of patients with insomnia can be delineated, in whom the PLMS have well defined characteristics (strict periodicity, highest prevalence in the first