ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2023, Vol. 39, No.(5): Pg. 1264-1271 This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC- BY). Published by Oriental Scientific Publishing Company © 2018 Design of Novel Thiohydantoin Derivatives and Exploration Their Physico-Chemical Parameters PRASHANT A. GOTMARE and SANJAY V. KOLHE Department of Chemistry, Shri Shivaji Arts, Commerce and Science College, Akot, Dist.Akola-444101, (Maharashtra), India. *Corresponding author E-mail: prashantpatilchem2763@gmail.com http://dx.doi.org/10.13005/ojc/390520 (Received: August 28, 2023; Accepted: October 11, 2023) ABSTRACT Thiohydantoin analogues was heterocyclic non-aromatic five membered cyclic compounds obtained from aurones derivatives. In this article, we synthesized novel thiohydantoin derivatives and exploration of physicochemical parameters like density, viscosity, ultrasonic velocity, intermolecular free path, adiabatic compressibility etc. The structural elucidation of resultant compounds was done on the basis 1 HNMR, IR, Mass etc. The present study revealed that, thiohydantoin analogues shows more structure making capacity in DMSO than DMF. Keyword: 2-Thiohydantoin, Physicochemical properties, Viscosity, Refractive index. INTRODUCTION 2-Thiohydantoin is an important class of compounds within chemistry. It is a sulphur derivative of hydantoin which is obtained by replacing the oxygen atom of carbonyl group by sulphur. Thiohydantoin is a intermediate to synthesis of many drugs 1-12 . In solid state thiohydantoin shows π-π stacking, hydrogen bonding which is important in pharmaceutical industries. 13-16 One of the most important things that drew the attention of researchers to synthesized thiohydantoin due to wide range of application like anti- inflammatory, anti-ulcer 17 , antifungal, antibacterial 18 , HIV 19 , hypolipidemic 20 , antimutagenic 21 , against HSV 22 , anticarcinogenic 23 , on tuberculosis 24 and pesticide 25 , derivatives of thiohydantoin are also used as a fungicide 26 , N-phenyl derivative of 2-Thiohydantion shows antiparasitic activity against Trypanosoma brucei species 27 . K.H. Chikhalia et al., 28 reported a series of thiohydantoin derivatives having ethyl linked 3,4-dimethoxyphenylethyl thiourea derivatives with styryl bridge possessing antibacterial properties as well as anti HIV activity. Abubshait S.A. 29 synthesized some 2-thiohydantoin drivatives and reported anticancer and antimicrobial properties against Gram-positive and Gram-negative bacteria. Kolhe S.V. 30 prepared 2-thiohydantoin derivatives by mixing aurones derivative with suitable thiourea by refluxing with KOH and ethaonol as a solvent and reported antimicrobial properties using microbes such as