_____________________________________________________________________________________________________ *Corresponding author: E-mail: nwaforcharles3@gmail.com; Asian Research Journal of Gynaecology and Obstetrics 6(2): 24-31, 2021; Article no.ARJGO.72641 Attenuation of Reproductive Dysfunctions by Hydroethanolic Leaf Extract of Fleurya aestuans in Diabetic Rats Green I. Kinikanwo 1 , Charles C. Nwafor 2* and Weleh I. Iyke 3 1 Department of Obstetrics and Gynecology, Faculty of Clinical Sciences, College of Health Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Nigeria. 2 Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, Madonna University, PMB 48, Elele, Nigeria. 3 Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. David Kitara Lagoro, Gulu University, Uganda. Reviewers: (1) Tanmay Chudasama, India. (2) Hanan Tawfeek Emam, Benha University, Egypt. (3) K.Latha, Dr.MGR Medical University, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/72641 Received 10 June 2021 Accepted 16 August 2021 Published 20 August 2021 ABSTRACT Diabetes mellitus produces excessive reactive oxygen species (ROS) in the male gonads resulting to impairments of steroidogenesis and spermatogenesis. Fleurya aestuans is an extremely basic plant with therapeutic properties but it’s frequently viewed as a weed in Nigeria. The present study therefore attempts to examine the effects of the hydroethanolic leaf extract of Fleurya aestuans on reproductive dysfunctions of diabetic rats. The rats were randomly assigned into seven groups of five rats each. Diabetes was induced in all the test groups 2-7 by intra-peritoneal injection of 150mg/kg bwt of alloxan monohydrate. Rats of the first group served as control and were only allowed rat feed and tap water ad libitum. Rats of the second group served as alloxan only group (ALXOG) and received 150mg/kg bwt of alloxan monohydrate. The third, fourth and fifth groups served as low dose extract group (LDEG), medium dose extract group (MDEG) and high dose Original Research Article