Journal of Biomedical and Pharmaceutical Research Available Online at www.jbpr.in CODEN: - JBPRAU (Source: - American Chemical Society) NLM (National Library of Medicine): ID: (101671502) Index Copernicus Value 2018: 88.52 Original Research Article Volume 10, Issue 1: January-February: 2021, Page No. 40-51 ISSN (Online): 2279-0594 ISSN (Print): 2589-8752 40 | Page PROSPECTIVE ANALYSIS OF IMPACT OF PHARMCOTHERAPY ADHERENCE ON TREATMENT EFFECTIVENESS IN POST OPERATIVE HEART PATIENTS Samridhi Khandelwal 1 *, Dr. Vandana Sharma 2 , Ramesh Pareek 3 , Shailendra Tripathi 3 , Shankar Soni 3 , Pawan Upadhyay 1 1 Research Scholar, Arya College of Pharmacy, Jaipur 2 Professor, Arya College of Pharmacy, Jaipur 3 Asso. Professor, Arya College of pharmacy, Jaipur Article Info: Received 13 January 2020; Accepted 14 February 2021 DOI: https://doi.org/10.32553/jbpr.v10i1.836 Corresponding author: Samridhi Khandelwal Conflict of interest statement: No conflict of interest Abstract Myocardial infarction is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomese blocked following the rupture of an atherosclerotic plaque, which then leads to the formation of a blood clot (coronary thrombosis). This event can also trigger coronary vasospasm. Ischemia induces profound metabolic and ionic perturbations in the affected myocardium and causes rapid depression of systolic function. Prolonged myocardial ischemia activates a "wavefront" of cardiomyocyte death that extends from the subendocardium to the subepicardium. Mitochondrial alterations are prominently involved in apoptosis and necrosis of cardiomyocytes in the infarcted heart. This prospective, pilot, observational study performed confirmed the hypothesis that systematic identifications and interventions administered through continued physician follow-up and patients counselling will improve adherence to therapy and therefore improvement in treatment effectiveness by lowering especially Troponin level ,CPK and quality of life in MI patients. Study was shown that lack of proper knowledge about disease and patients counseling and chronic treatment, most of patients takes disease and its treatment lightly and shows lower adherence attitude. The study analysis shown that female are generally more aware than males for adherence. Study analysis concluded that there was significant reduction in their Troponin level and CPK values in different comparison groups after each level of follow up. Statistical analysis concluded that patients with adherence ˃ 95% showed significant reduction in Troponin level and CPK values and patients with age group ≤50 shows more adherence than older. Most heart patients recorded with hypertension and Coronary Artery Diseases only few ones with diabetic complications. During study patients shows good control over their blood pressure and only few adverse events but no complications occur during study period. 1. INTRODUCTION Heart attack is a medical emergency, usually occurs when a blood clot blocks blood flow to the heart leads to the death of a segment of heart muscle. When it happens, a person experiences chest pain and electrical instability of heart tissue. Blockage is most often a build up of fat, cholesterol and other substances. Heart attack can also be termed as myocardial infraction, cardiac infraction and coronary thrombosis. Myocardial infarction ("heart attack") is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomes blocked following the rupture of an atherosclerotic plaque, which then leads to the formation of a blood clot (coronary thrombosis). This event can also trigger coronary vasospasm. Ischemia induces profound metabolic and ionic perturbations in the affected myocardium and causes rapid depression of systolic function. Common heart attack signs and symptoms include:Pressure, tightness, pain, or a squeezing or aching sensation in your chest or arms that may spread to your neck, jaw or back, Nausea, indigestion, heartburn or abdominal pain, oppressive pain, Shortness of breath, Cold sweat, Fatigue, Lightheadedness or sudden dizziness, Absence of chest-wall tenderness on palpation METHODS 2.1 STUDY PROCEDURE 2.1.1 Study design