Magnesium Research 2012; 25 (2): 89-98 ORIGINAL ARTICLE Increase in intra-abdominal pressure raises brain venous pressure, leads to brain ischaemia and decreases brain magnesium content Bozena Jarosz 1 , Wojciech Dabrowski 2 , Andrzej Marciniak 3 , Piotr Wacinski 4 , Ziemowit Rzecki 2 , Edyta Kotlinska 2 , Jacek Pilat 5 1 Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin; Poland; 2 Department of Anaesthesiology and Intensive Therapy, Medical Uni- versity of Lublin, Poland; 3 Department of Physiology, Medical University of Lublin, Poland; 4 Department of Cardiology, Medical University of Lublin; Poland; 5 Department of General Surgery, Transplantology and Clinical Nutrition, Medical University of Lublin, Poland Correspondance : Wojciech Dabrowski, Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin; Jaczewskiego 8; 20-954 Lublin; Poland. <w.dabrowski5@yahoo.com> Abstract. Background. Intra-abdominal hypertension (IAH) may increase brain venous pressure, which may lead to brain injury. The aim of the present study was to analyse the effect of IAH on brain venous pressure and brain total and ionised magnesium (tMg and iMg), calcium (Ca) and zinc (Zn) contents in rats. Material and methods. Forty four adult Wistar rats were examined. Ani- mals were divided into two groups: control, and IAH: rats with intra-abdominal pressure (IAP) elevated to 25 mmHg. IAP was measured directly in the abdomi- nal cavity. After retrograde cannulation of the jugular vein, the jugular venous pressure (JVP) was measured as the brain venous pressure. JVP and IAP were noted after induction of anaesthesia, immediately following induction of IAH and 90 min after induction of IAH. In all rats, brains were removed for biochemi- cal and histological analysis. Results. Biochemical analysis was performed in 30 rats, histological visualisation in 14. IAP elevated to 25 mmHg increased JVP in the IAH group. After 90 min, JVP decreased; however, its value was still higher compared with pre-IAH. In the IAH group, tMg and iMg were signifi- cantly lower than in the control group. Moreover, Ca and Zn levels were higher in the IAH group compared with the control group. The histological examina- tion showed changes indicative of ischaemic neuronal cell stress. Conclusions. Firstly, increase in IAP elevates JVP. Secondly, raised JVP decreases tMg and iMg. Thirdly, raised JVP increases the Ca and Zn content in the rat brain. Fourthly, IAH leads to changed characteristics of brain ischaemia. Key words: intra-abdominal pressure, intra-abdominal hypertension, brain ischaemia, brain venous hypertension, magnesium, calcium, zinc Intra-abdominal pressure (IAP) is defined as the steady-state pressure in the peritoneal cavity [1]. The normal value of IAP ranges from 5 to 7 mmHg, but its elevation to as high as 12 mmHg is not clinically important. IAP higher than 12 mmHg is called intra-abdominal hypertension (IAH); however, organ dysfunction resulting from IAH is most frequently observed at IAP higher than 20 mmHg and is referred to as abdominal compartment syndrome (ACS) doi:10.1684/mrh.2012.0310 89 To cite this article: Jarosz B, Dabrowski W, Marciniak A, Wacinski P, Rzecki Z, Kotlinska E, Pilat J. Increase in intra-abdominal pressure raises brain venous pressure, leads to brain ischaemia and decreases brain magnesium content. Magnes Res 2012; 25(2): 89-98 doi:10.1684/mrh.2012.0310 Copyright © 2017 John Libbey Eurotext. Téléchargé par un robot venant de 54.191.40.80 le 27/06/2017.