Available online at www.ijournalse.org Emerging Science Journal (ISSN: 2610-9182) Vol. 8, No. 2, April, 2024 Page | 372 SY-MIS Project: Biomedical Design of Endo-Robotic and Laparoscopic Training System for Surgery on the Earth and Space José Cornejo 1, 2, 3* , Jorge Cornejo 4 , M. Vargas 1 , M. Carvajal 5 , Paul Perales 6 , G. Rodríguez 7 , C. Macias 7, 8 , S. Canizares 9 , Paola Silva 10 , Robert F. Cubas 11 , M. C. Jimenez 11 , Eddy P. Lincango 12 , Luis Serrano 13 , Ricardo Palomares 14 , S. Aspilcueta 14 , Rocio Castillo-Larios 4 , Lorna A. Evans 4 , J. A. De La Cruz-Vargas 1 , Marcelo Risk 15 , Rafael J. Grossmann 16 , Enrique F. Elli 4 1 Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Peru. 2 Center for Space Systems (C-SET), Canada. 3 Space Generation Advisory Council, Vienna, Austria. 4 Department of Surgery, Mayo Clinic, FL, United States. 5 Department of Surgery, Johns Hopkins University, MD, United States. 6 Miami Research Cancer Center, FL, United States. 7 Universidad Católica De Santiago de Guayaquil, Ecuador. 8 Hillsborough Community College, FL, United States. 9 Universidad San Francisco de Quito, Ecuador. 10 Universidad Tecnológica Equinoccial, Ecuador. 11 Department of Surgery, University of Miami, FL, United States. 12 CaTaLiNA - Cancer de Tiroides en Latino America, Quito, Ecuador. 13 Department of Surgery, University of Central Florida, FL, United States. 14 Research Group of Advanced Robotics and Mechatronics (GI-ROMA), Universidad Ricardo Palma, Lima, Peru. 15 Instituto de Medicina Traslacional e Ingenieria Biomedica (IMTIB) - CONICET- Instituto Universitario del Hospital Italiano - Hospital Italiano de Buenos Aires, Ciudad de Buenos Aires, C1199, Argentina. 16 Portsmouth Regional Hospital, NH, United States. Abstract Despite the location (Earth or Space), surgical simulation is a vital part of improving technical skills and ensuring patients' safety in the real procedure. The purpose of this study is to describe the Space System for Minimally Invasive Surgery (SY-MIS©) project, which started in 2016 under the supervision of the Center for Space Systems (C- SET). The process connects the best features of the following machines: Biomedik Surgeon, Space Biosurgeon, SP-LAP 1, and SP-LAP 2, which were defined using the VDI 2221 guidelines. This research uses methods based on 3 standards: i) Biomedical design: ISO 9001-13485 / FDA 21 CFR 820.30 / ASTM F1744-96(2016); ii) Aerospace human factors: HF-STD-001; iii) Mechatronics design: VDI 2206. The results depict the conceptual biomedical design of a novel training system named Surgical Engineering and Mechatronic System (SETY©), which integrates the use of 2 laparoscopic tools and 2 anthropomorphic mini-robotic arms (6 DOF). It has been validated by the Evaluation of Technical Criteria, getting a total score of 90% related to clinical assessment, machine adaptability, and robustness. The novelty of the research lies in the introduction of a new procedure that covers the simultaneous use of laparoscopic and robotic systems, named Hybrid Cyber-Physical Surgery (HYS©). In conclusion, the development of SY-MIS© promotes the use of advanced technologies to improve surgical procedures and human- machine medical cooperation for the next frontier of habitability on other planets. Keywords: Engineering Design; Biomedical Technologies; Medical Mechatronics; Surgical Robotics; Aerospace Medicine. Article History: Received: 03 December 2023 Revised: 27 February 2024 Accepted: 09 March 2024 Published: 01 April 2024 * CONTACT: jose.cornejo@ieee.org DOI: http://dx.doi.org/10.28991/ESJ-2024-08-02-01 © 2024 by the authors. Licensee ESJ, Italy. This is an open access article under the terms and conditions of the Creative Commons Attribution (CC-BY) license (https://creativecommons.org/licenses/by/4.0/).