Citation: Hira Tahir, Muhammad Sajid, Asif Ali, Hafiza Sania Saeed, Imrana Siddique, Rabia Abbasi, Muhammad Haseeb Bilal, Muhammad Adnan (2022). New Insights in Biological Development of Novel Varieties with Antioxidant, Antimicrobial, Antiparasitic, DNA Protection Activities and Future Perspectives. Saudi J Pathol Microbiol, 7(3): 111-116. 111 Saudi Journal of Pathology and Microbiology Abbreviated Key Title: Saudi J Pathol Microbiol ISSN 2518-3362 (Print) |ISSN 2518-3370 (Online) Scholars Middle East Publishers, Dubai, United Arab Emirates Journal homepage: https://saudijournals.com Review Article New Insights in Biological Development of Novel Varieties with Antioxidant, Antimicrobial, Antiparasitic, DNA Protection Activities and Future Perspectives Hira Tahir 1 , Muhammad Sajid 2 , Asif Ali 3* , Hafiza Sania Saeed 4 , Imrana Siddique 5 , Rabia Abbasi 6 , Muhammad Haseeb Bilal 7 , Muhammad Adnan 8 1 Department of Botany, Government College Women University, Faisalabad, Pakistan 2 Department of Botany, Hazara University, Mansehra, Pakistan 3 Deprament of Botany, University of Karachi, Pakistan 4 Department of Botany, The Woman University, Multan, Pakistan 5 Deparment of Botany, University of Agriculture Faisalabad, Pakistan 6 Department of Botany, PMAS-Arid Agriculture University, Rawalpindi, Pakistan 7 Department of Botany, Government College University, Faisalabad, Pakistan 8 Deprtment of Zoology, Ghazi University, Dera Ghazi Khan, Pakistan DOI: 10.36348/sjpm.2022.v07i03.005 | Received: 29.01.2022 | Accepted: 04.03.2022 | Published: 13.03.2022 *Corresponding author: Asif Ali Deprament of Botany, University of Karachi Pakistan Abstract Medicinal plants are most valuable source of different natural compounds and safer than the chemicals that directly used for the treatment of high risk diseases. The compounds that present in the medicinal plants are monoterpenes, flavonoids, and phenolics. The ultimate goal of the using of medicinal herbs are inhibiting the growth of the infectious particles that causing variety of diseases. Medicinal plants have been used in order to control the growth of infectious bacteria in as some of them deviling the resistance due to changing endearments for example, Enterococcus faecium and Klebsiella pneumonia. Many of the plant extracts such as N.sativa seeds have been used as natural booster for targeting the lethal pathogens and causing the cellular toxicities While, Commelina africana L and Elephantorrhiza elephantine that binds with living cells by damaging’s the membranes of the toxic pathogens. The production of the free radicals due to stress or any environmental conditions may increase the risk of damage to DNA molecules. These free radicals binds to the double binds of the DNA molecule inhibit their functions in order to replicate for further central dogma processing. It give rise the production of peroxyl radicals species due to consecutive attack to the DNA molecule. Keywords: Medicinal plants, Biological activities, cellular toxicities, free radicals , peroxyl radicals. Copyright © 2022 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited. INTRODUCTION Medicinal plants are the most valuable source of the antioxidants, flavonoids, and variety of enzymes. These are natural source for inhibiting the infections caused by the different types of microbes. One the example is the antioxidants ability to interact the microbes in such as way that boost the immunity. These plants also possessing the characteristics such as adsorbing and neutralizing free radicals, by decomposing the peroxides [1, 2]. The byproducts of the free radicals then selected from the body in order to reduce the toxicity problems. There is need to design the natural products that act on the free radicals causing agents because of their increasing interest in the medicinal market and hence increase the overall agricultural growth of certain crops by promoting the beneficial rhizobacteria. While on the other hand, increasing of the scavenging activity of certain medicinals acting as natural herbs by replacing the toxic chemicals in different ways both in industrial and commercial steps. of free radicals and inhibition of enzymes involved in free radical production [4, 5]. There are different options for extracting the natural products but most of them are costly and les significant due to poor separation of high quality ingredients from the extracts. The extracts of various medicinal plants have been used for treating the different diseases such as diabetes, liver and lowering of the blood pressure but the high use of toxic chemicals in the drugs can cause serious toxicities in