Citation: Jahan N, Firoz AMA, Nowroz ASM, Islam MS, Mortaz RE, Shafiq S, Zaman KMS, Rahman AKMS. Association of C- Reactive Protein and Glycated Hemoglobin among Type 2 Diabetic Adults. Sch J App Med Sci, 2024 Oct 12(10): 1334-1340. 1334 Scholars Journal of Applied Medical Sciences Abbreviated Key Title: Sch J App Med Sci ISSN 2347-954X (Print) | ISSN 2320-6691 (Online) Journal homepage: https://saspublishers.com Association of C- Reactive Protein and Glycated Hemoglobin among Type 2 Diabetic Adults Nasrin Jahan 1* , Abu Md. Ahsan Firoz 2 , A S M Nowroz 1 , Md Saiful Islam 1 , Rubaiyat-E-Mortaz 1 , Sabrina Shafiq 1 , Khan Md. Shahariar Zaman 1 , A. K. M Shahidur Rahman 3 1 Assistant Professor, Department Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh 2 Medical Officer, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh 3 Medical Officer, Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh DOI: https://doi.org/10.36347/sjams.2024.v12i10.012 | Received: 03.09.2024 | Accepted: 10.10.2024 | Published: 14.10.2024 *Corresponding author: Dr. Nasrin Jahan Assistant Professor, Department Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, Email: nasrinjahan1101@gmail.com Abstract Original Research Article Background: Diabetes mellitus (DM) is a complex metabolic disorder and is a major global health problem. An increasing amount of evidence suggests that chronic subclinical inflammation is one of the triggering factors in the onset of type 2 diabetes mellitus (T2DM). Objective: The current study was designed to determine the association of C- reactive protein (CRP) and glycated hemoglobin (HbA1c) in T2DM patients. Methods: This cross-sectional study was carried out at Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh between March 2017 to February 2018. Total 80 adult patients of newly diagnosed T2DM were included in this study. A detailed clinical history was recorded and relevant physical examinations were done. The complete blood count (CBC), C-reactive protein (CRP), fasting blood glucose (FBG) and HbA1c were done accordingly. Data were analyzed and compared by statistical tests. Results: The mean age of the study patients was 45.06±11.08 years with female predominance. More than half (53.7%) of the study patients were in age group 41-59 years. Majority (65%) of the study patients was overweight/obese. It was observed that, mean(±SD) FBG, HbA1c and CRP levels were 8.97±2.41 mmol/L 8.54±2.08% and 8.98±4.85 mg/L respectively. Pearson correlation analysis revealed that CRP has a significant positive correlation with HbA1c (r= 0.457, p< 0.001). Conclusion: This study concluded that CRP has a significant positive association with HbA1c in adult T2DM patients. CRP can be used as a valuable and effective tool for monitoring T2DM. Keywords: C-Reactive Protein (CRP), Diabetes Mellitus (DM), Glycated Hemoglobin (HbA1c), Type 2 Diabetes Mellitus (T2DM). Copyright © 2024 The Author(s): This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY-NC 4.0) which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited. 1. INTRODUCTION Type 2 diabetes mellitus (T2DM) is recognized as one of the major health issues worldwide. Diabetes mellitus (DM) is a chronic, metabolic disorder characterized by uncontrolled hyperglycemia that results from a decrease in the physiologic efficiency of insulin, an absolute or relative lack of insulin secretion, or both [1]. The estimated global prevalence of DM was 8.8% in 2015, and by 2040, it is expected to increase up to 10.4% [2]. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction and failure of various organs particularly the eyes, kidneys, nerves, heart and blood vessels [1]. DM is regarded as one of the leading causes of death and disability globally [3]. Glycated hemoglobins are glucose-derived products of normal adult hemoglobin. Glycated hemoglobin (HbA1c), produced by the condensation of glucose with N-terminal valine of each β-chain of HbA [4]. It is formed by a slow irreversible non-enzymatic reaction between hemoglobin and glucose. It represents the integrated values for glucose over the preceding 6-8 weeks [5]. HbA1c is now regarded as a much more robust parameter than fasting plasma glucose for detecting and monitoring the impairment of glucose homeostasis in the general adult population [6]. Previous studies suggest that chronic subclinical inflammation may be associated with insulin resistance and precede the development of clinically overt type-2 diabetes mellitus [7-11]. Patients with type- Medicine