International Journal of Advanced Biotechnology and Research (IJABR) ISSN 0976-2612, Online ISSN 2278–599X, Vol-14, Issue3, 2023, pp11-15 www.bipublication.com Research Article Studying of antimicrobial activities of resins and ether parts of resins of Ferula tadshikorum Dildora Barakaeva 1* , Farkhod Eshboev 2 , Nuriddin Mukarramov 2 , Salima Aripova 2 , Damir Mansurov 2 and Shakhnoz Azimova 2 1 Tashkent state Agrarian University; 2 S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77, Mirzo Ulugbek Str., 100170, Tashkent, Uzbekistan; *Correspondence: barakayevadildora0@gmail.com [Received 19 June-2023, Accepted 22 July-2023, Published 26 July-2023] Abstract In this study, antimicrobial activities of resins and ether parts of resins of Ferula tadshikorum were investigated. Ether parts of resin showed potential antimicrobial activities (13,5±0.15 mm - 16.21±0.12 mm). Therefore, the chemical contents of volatile parts of resin were determined by the GC-MS method in order to identify the major compounds responsible for the observed antimicrobial activity (Table 2). The chemical composition of the volatile fraction of F. tadshikorum ether has been studied in several research papers. The composition of the volatile fraction can vary depending on factors such as the geographic location and harvesting time of the plant, as well as the extraction method used. Keywords: Ferula tadshikorum, antimicrobial activity, GC-MS method, resin, ether. Introduction. The genus Ferula is the third largest and well- known genus of the family Apiaceae - celery. Currently, about 180 species of Ferula are known. The genus is distributed mainly throughout Central and Southwest Asia (especially in Iran and Afghanistan), the Far East, Northern India and the Mediterranean. The genus Ferula is characterized by the presence of oil resins (asafoetida, sagapenum, galbanum) and their use in folk and traditional pharmaceuticals [1]. Ferula is a Latin word meaning "vehicle" or "carrier". The main phytochemicals present in plants of the genus Ferula are coumarins, coumarin esters, sesquiterpenes, sesquiterpene lactones, monoterpenes, monoterpene coumarins, prenylated coumarins, sulfur-containing compounds, phytoestrogens, flavonoids, carbohydrates and other compounds [2]. This genus is distinguished by the content of valuable groups of chemical compounds in medicinal plant species, namely, the content of odorous volatile components as essential oils, which cause their widespread use for various biological and pharmacological purposes. Numerous biological activity of chemical components of