ORIGINAL ARTICLE Journal of Evolution of Medical and Dental Sciences/ Volume 2/ Issue 25/ June 24, 2013 Page 4554 PREVALENCE OF CARCINOMA IN SYMPTOMATIC GALL STONE DISEASE- A STUDY FOLLOWING CHOLECYSTECTOMY Manisha Nigam 1 , Renu Ranwaka 2 , Brijendra Nigam 3 , Mahendra Singh 4 ,T. P.Devpura 5 . 1. Assistant Professor. Department of Surgery, Rama Medical College, Mandhna, Kanpur. 2. Professor, Department of Surgery, Rama Medical College, Mandhna, Kanpur. 3. Laparoscopic & General. Surgeon, MB Super speciality Hospital. Kanpur. 4. Professor, Department of Pathology, GSVM Medical College. Kanpur. 5. Professor, Department of Surgery, Rama Medical College, Mandhna, Kanpur. CORRESPONDING AUTHOR: Dr. Manisha Nigam, 13 Hemant Vihar, Sector -3, Barra-2, Kanpur: 208027. E-mail: brijendramanisha@yahoo.com HOW TO CITE THIS ARTICLE: Manisha Nigam, Renu Ranwaka, Brijendra Nigam, Mahendra Singh, T.P. Devpura. “Prevalence of Carcinoma in Symptomatic Gall Stone Disease- A study following Cholecystectomy”. Journal of Evolution of Medical and Dental Sciences 2013; Vol2, Issue 25, June 24; Page: 4554-4558. ABSTRACT: OBJECTIVE- To determine the prevalence of carcinoma of the gallbladder in the specimens following routine cholecystectomy. STUDY DESIGN- Observational case series study Place & Duration of study- Department of Surgery, Rama Medical college Hospital and Research center, from April 2009 to March 2013. MATERIALS AND METHOD-All patients with symptomatic gallstone disease of both sex having age range between 15 to 70 year were included. Patients with pre diagnosed Gallbladder malignancy, Gallbladder mass, Empyema Gallbladder and Gallstones associated with obstructive jaundice were excluded. All cholecystectomized gall bladder specimens were sent for histopathological examination. RESULTS-Five hundred and twenty patients (520) including 104 males and 416females (M: F ratio 1:4) aged15-70 year and having a mean age of 41.7 year (± SD 2.4), were included in this retrospective study. Commonest presentations were pain in the right hypochondrium and a positive Murphy’s sign (87.71%) followed by dyspepsia (55%), nausea, vomiting (40%), pyrexia (31.92%) and weight loss (05%). Twenty two (4.23%) patients had a diagnosis of malignancy of gallbladder at histopathology examination. Mean age for patients with malignancy was 55.25 year with a male to female ratio of 01:10. Well differentiated adenocarcinoma was reported in 45.45% cases, moderately differentiated in 36.36%, poorly differentiated in 09.09% and undifferentiated in 09.09%patients CONCLUSION-Though early detection and treatment has declined the incidental Gall Bladder carcinoma occurrence, but routine histopathology of cholecystectomized Gall Bladder is necessary for early detection of Gall Bladder Cancer. KEY WORDS-Cholecystectomy, Gallstones, Histopathology. INTRODUCTION: The prevalence of gallbladder cancer, the commonest biliary malignancy, shows geographical and racial variations. It is reported to be rare in India. However, the incidence