Journal Pre-proof First description of an unusual novel double mutation in MECP2 co-occurring with the m.827A>G mutation in the MT-RNR1 gene associated with Angelman-like syndrome Marwa Kharrat, Chahnez Triki, Marwa Maalej, Sihem Ncir, Marwa Ammar, Fatma Kammoun, Faiza Fakhfakh PII: S0736-5748(19)30164-9 DOI: https://doi.org/10.1016/j.ijdevneu.2019.10.002 Reference: DN 2394 To appear in: International Journal of Developmental Neuroscience Received Date: 26 June 2019 Revised Date: 1 September 2019 Accepted Date: 7 October 2019 Please cite this article as: Kharrat M, Triki C, Maalej M, Ncir S, Ammar M, Kammoun F, Fakhfakh F, First description of an unusual novel double mutation in MECP2 co-occurring with the m.827A>G mutation in the MT-RNR1 gene associated with Angelman-like syndrome, International Journal of Developmental Neuroscience (2019), doi: https://doi.org/10.1016/j.ijdevneu.2019.10.002 This is a PDF ﬁle of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the deﬁnitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its ﬁnal form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier.