IJOD, 2018, 6(2), 136-141 www.drugresearch.in Indian Journal of Drugs, 2018, 6(2), 136-141 ISSN: 2348-1684 REVIEW: CHOCOLATE FORMULATION AS DRUG DELIVERY SYSTEM Shivani A. Chaudhari, Rohini R. Devare, Prajakta S. Dewang, Varsha B Patil, Amruta M. Patil, Dr. Sunil P. Pawar P.S.G.V.P. M’S College of Pharmacy, Shahada-425409, Dist.-Nandurbar, Maharashtra. * For Correspondence: P.S.G.V.P. M’S College of Pharmacy, Shahada-425409, Dist.-Nandurbar, Maharashtra. ABSTRACT Chocolate/cocoa has been known for its good taste and proposed health effects for centuries. Most of the drugs are bitter due to which oral administration of these drugs leads to patient incompliance especially in children. To overcome this limitation, it is advisable to formulate dosage form, which is most acceptable for paediatric patients. Chocolate is one of the most palatable and favourite in children, so we have developed chocolate drug delivery system. Chocolate tastes good; it stimulates endorphin production, which gives a feeling of pleasure. It contains serotonin, which acts as an anti- depressant. It contains theobromine, caffeine and other substances, which are stimulants. Cocoa can also protect nerves from injury and inflammation, protect the skin from oxidative damage from UV radiation in topical preparations, and have beneficial effects on satiety, cognitive function, and mood. Medicated chocolate is prepared by using chocolate base and drug is incorporated to prepared chocolate base. The medicated chocolate can be evaluated for its appearance, moisture content, viscosity, blooming test, drug content determination and in vitro drug release. This review paper focused on health importance and usage of medicated as well as conventional chocolates. KEY WORDS: Medicated Chocolate, Cocoa, Paediatrics, Chocolate Formulation. Received: 30.01.2018 Accepted: 22.06.2018 Access this article online Website: www.drugresearch.in Quick Response Code: INTRODUCTION hocolate is highly sophisticated and much infinitely adaptable food that can be combined to create completely different taste and consistency sensations. Chocolate is an anhydrous medium resistant to microbial growth and hydrolysis for water-sensitive active agents. Chocolate abundantly contains compounds such as saturated fat, polyphenols, sterols, di and triterpenes, aliphatic alcohols, methylxanthines flavones, antioxidants Cocoa is the main ingredient of chocolate and it is loaded Chocolate in polyphenols. Chocolate containing the drug in suitable quantity is known as medicated chocolate. There are four types of taste modalities, salty, sour, bitter, sweet through the combination of these elements we can detect the “flavours” Children’s tastes sensation is much differed than adult infants and more over children prefer sweet-tasting substance. Chocolate have been shown to help our body produce chemical known as “Serotonin”. It makes feel relaxed. Further chocolate is also having some advantages like quick onset of action, reduction in the drug dose of manufacture and scale, increases drug loading capacity. Some drugs are bitter in taste due to which oral administration of bitter drugs leads to patient incompliance especially in children. To overcome this limitation, it is advisable to formulate dosage form, which is most acceptable for paediatric patients. Chocolate is one of the most palatable and favourite in children, so we have developed chocolate drug delivery system. Chocolate (in some regions also named bittersweet chocolate, semi-sweet chocolate, dark chocolate or “chocolate fondant”) shall contain, on a dry C