Study of Malaria Parasite with Special Reference to Liver Function Test of the Patient Attending at TMU Hospital Moradabad (U.P) Ratnendra Bisht 1* , Madhubala Mishra 2 , Sandhya Mishra 2 1 Demonstrator, Department of Microbiology, KM Medical college Mathura (UP). 2 Senior Demonstrator, Department of Microbiology, RNT Medical college Udaipur (RJ) 33 | Page Original Article www.iabcr.org International Archives of BioMedical and Clinical Research | Jan-Mar 2017 | Vol 3 | Issue 1 Section – Microbiology ABSTRACT Background: Malaria is an important infectious vector borne disease caused by a Plasmodium species. Liver involvement in severe Plasmodium falciparum infection is commonly a significant cause of morbidity and mortality among humans. Objective: In this study, we show the correlation of malaria positive cases with liver derangement. Methods: The present study had been conducted in Teerthankar Mahaveer Medical college Hospital and Research Center, Moradabad, U.P. from February 2014 to January 2015 on both IPD & OPD patients .Results: The present study included 200 clinically suspected cases of Malaria with derange Liver function. 67.5% patients show increased level of Total and indirect bilirubin followed by 45% of patient shows increased level of direct bilirubin. 27.5% patient’s shows increased level SGPT followed by 40% of SGOT. Conclusions: Deranged liver functions are commonly seen as a complication of severe malarial infection. Key words: : plasmodium, liver function, malaria INTRODUCTION Malaria is an important infectious vector borne disease caused by a Plasmodium species and it has been estimated that worldwide there are 300-500 million cases of malaria per year and 1.5-2.7 million deaths due to it. Malaria is the most important protozoal parasitic disease of humans affecting more than one billion people worldwide and causing between 1 and 3 million deaths each year. .[1] Malaria is caused by obligate intracellular parasites, which live in host erythrocytes and remodel these cells to provide optimally for their own needs. .[2] Malaria parasite belongs to the genus Plasmodium. There are 156 named species of Plasmodium which infect various species of vertebrates. Four are known to infect humans: P. Falciparum, P. vivax, and P. malariae and P. ovale. P. vivax has widest distribution, extending throughout the tropics, subtropics, subtropics and temperate zones. Plasmodium falciparum is the most dangerous form of malaria, with the highest rates of complications and mortality. It is much more prevalent in sub- Saharan Africa than in many other regions of the world; is most African countries, over 75%of cases were due to P. Falciparum, whereas in most other countries with malaria transmission, other, less virulent plasmodial species predominate. P. falciparum is the most pathogenic of the human plasmodium species. It causes; sub-tertian fever, malignant fever, pernicious malaria, cerebral malaria and algid malaria. .[3] Plasmodium. Vivax (P. vivax) malaria is a public health problem that puts billions of the world’s populations at risk of infection as highlighted in the World Malaria Report 2010. [4] P. vivax has a greater ability to survive in non- conducive environments; however, it is still considered to run a relatively benign disease course as compared to Plasmodium falciparum. Access this article online Website: www.iabcr.org Quick Response code DOI: 10.21276/iabcr.2017.3.1.10 Received:03.02.17| Revised:16.02.17| Accepted:17.02.17 Corresponding Author Dr. Ratnendra Bisht, Department of Microbiology, KM Medical college Mathura (UP), India. Copyright: © the author(s) and publisher. IABCR is an official publication of Ibn Sina Academy of Medieval Medicine & Sciences, registered in 2001 under Indian Trusts Act, 1882. This is an open access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.