*Corresponding Author: deepakman12@gmail.com 66 DOI: https://doi.org/10.52756/ijerr.2024.v44spl.006 Int. J. Exp. Res. Rev., Vol. 44: 66-75 (2024) Medicinal Plants Approach for Diabetes Mellitus-A Computational Model Khushali Tyagi 1 , Deepak Kumar 1* and Richa Gupta 2 1 Department of Applied Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, India; 2 Management Education & Research Institute, Janakpuri, New Delhi, India E-mail/Orcid Id: KT, khushalityagi.179@gmail.com, https://orcid.org/0009-0000-9071-5146; DK, deepakman12@gmail.com, https://orcid.org/0000-0001-9419-8895; RG, rchgupta8@gmail.com, https://orcid.org/0009-0005-2134-8705 Introduction Diabetes mellitus, which is often known as type 1 and type 2 diabetes, is a metabolic syndrome (Sarkar et al., 2023; Roy et al., 2023; Tyagi et al., 2024). In type 1 diabetes, β-cells are destroyed, resulting in the pancreas generating less insulin. In type 2 diabetes, a sufficient number of β-cells are produced but not utilized by the body to allow insulin to bring glucose into the cells (Pramanik, 2018; Biswas et al., 2023; Jaiswal and Gupta, 2023; Sur et al., 2023). To treat diabetes, many allopathic and ayurvedic treatments are available (Dhakar and Tare, 2023). A vital part of controlling diabetes mellitus is the use of medicinal plants (Acharya et al., 2023; Pawar et al., 2023; Vikhe et al., 2024). Insulin resistance or decreased pancreatic production are the two main causes of diabetes mellitus. Maintaining plasma glucose levels is important for the prevention of serious health problems. If the level of glucose goes beyond 120 mg/dl, it can result in long-term hyperglycemia which can increase the risk of developing kidney diseases (Roy and Robert, 2007). Diabetes can be treated with medicinal plants because of the presence of numerous active phytochemicals that are relevant for therapy, such as alkaloids, tannins, flavonoids and other components. To control blood sugar, inhibitors of DPP4 (Dipeptidyl- peptidase 4) help maintain the activity of glucagon-like Article History: Received: 20 th Mar., 2024 Accepted: 18 th Oct., 2024 Published: 30 th Oct., 2024 Abstract: The multidimensional metabolic syndrome that includes diabetes mellitus poses a serious threat to world health. There is an increasing interest in researching herbal remedies for their possible therapeutic advantages, even as traditional allopathic treatments continue to be widely used. This work throws light on the multiple ways of metabolism and biochemical interactions of medicinal plants in the control of glucose level, highlighting their crucial role in the process. The work clarifies several herbal extracts' efficacy and safety profiles, such as Aloe vera, Garlic, Gurmar, Bitter Melon, Neem, Tulsi, and through a thorough literature review and empirical evidence. These plants, which are abundant in bioactive substances like tannins, flavonoids, and alkaloids, show promise in treating insulin resistance, improving pancreatic function, and controlling blood sugar level. A further assessment of the rising risk associated with diabetes mellitus is discussed, and a differential equation model for diabetes mellitus is developed to minimize the complications. When using medicinal plants to treat diabetes, several factors are considered, including blood sugar level, sugar intake activity, and plasma insulin concentrations. The stability criterion for the mathematical model is examined through the system of differential equations. A representation highlighting the medicinal plants that can aid individuals with diabetes mellitus is provided. The blood sugar level, insulin generalization variable and plasma insulin concentration have all been measured at different points in time. Aloe vera, Gurmar, Garlic, Tulsi, Bitter Melon and Neem are among the medicinal plants selected for their demonstrated anti-hyperglycemic properties due to their easy availability in India. Mathematical solutions were calculated for every plant and proved to be steady. Keywords: Diabetes Mellitus, Medicinal Plants, Blood Glucose level, Insulin resistance Differential equation model. How to cite this Article: Khushali Tyagi, Deepak Kumar and Richa Gupta (2024). Medicinal Plants Approach for Diabetes Mellitus-A Computational Model. International Journal of Experimental Research and Review, 44, 66-75. DOI: https://doi.org/10.52756/ijerr.2024.v44spl.006