~ 70 ~ International Journal of Medical Anesthesiology 2020; 3(4): 70-73 E-ISSN: 2664-3774 P-ISSN: 2664-3766 IJMA 2020; 3(4): 70-73 Received: 19-08-2020 Accepted: 21-09-2020 Dr. Manisha Singh Department of Anesthesia, M.G.M. Medical College, Aurangabad, Maharashtra, India Dr. Pradnya S Joshi Prof. M.G.M. Medical College, Aurangabad, Maharashtra, India Dr. Sanhita J Kulkarni Prof. M.G.M. Medical College, Aurangabad, Maharashtra, India Dr. VM Sasturkar Prof. and H.O.D. M.G.M. Medical College, Aurangabad, Maharashtra, India Corresponding Author: Dr. Sanhita J Kulkarni Prof. M.G.M. Medical College, Aurangabad, Maharashtra, India A comparative study of two different doses of dexmedetomidine for attenuating the haemodynamic response to tracheal intubation Dr. Manisha Singh, Dr. Pradnya S Joshi, Dr. Sanhita J Kulkarni and Dr. VM Sasturkar Abstract Back ground: Reflex sympathetic discharge caused by laryngo-pharyngeal stimulus with laryngoscopy may lead to hypertension and tachycardia. It is one of the cause for morbidity during general anesthesia. We in our study compared the two doses of Dexmedetomidine1 μg/kg and 0.5 μg/kg for attenuating this response. Material and Methods: In this study ninety patients were randomly divided into two groups. Group A Received: 0.5μg/kg Injection Dexmedetomidine as bolus dose over 10 minutes & Group B - Received: 1μg/kg Injection Dexmedetomidine as a bolus dose over 10 minutes. The heart rate and blood pressure (Systolic, diastolic and mean) of the patient were noted at following intervals preoperative i.e. Baseline, during administration of the study drug at 2 minutes, 4 minutes, 6 minutes, 8 minutes, and 10 minutes, immediately at induction, At intubation and Post intubation at 1min, 5 min and 10 min. Statistical significance in mean difference was calculated using student’s t test. P value of < 0.05 was regarded as statistically significant and p < 0.001 was taken as highly significant. Results: Compared to the baseline all the hemodynamic parameters (HR, SBP, DBP and MAP) showed decrease during administration of the study drug which continued throughout the study period except at intubation and 1 min post intubation in both the groups. These values still remained below the baseline value. Highly significant difference in heart rate in both the groups was noted at 5 and 10min post intubation Group B showing more decrease than A(p=0.000, 0.001). Same statistical significance is noted in systolic blood pressure at induction and at 10 min. post intubation (p=0.000, 0.000). Mean blood pressure (p=0.03, 0.03) and diastolic blood pressure (p=0.000, 0.001) also showed more decrease in Group B than A at 5 and 10 min post intubation with high statistical significance. Conclusion: Dexmedetomidine in the dose of 0.5 μg/kg and 1μg/kg is effective in attenuating the hemodynamic response to laryngoscopy and tracheal intubation Keywords: Dexmedetomedine, Haemodynamic response, tracheal intubation Introduction Laryngoscopy and endotracheal intubation during general anesthesia result in hypertension and tachycardia. These haemodynamic changes are due to reflex sympathetic discharge caused by laryngo-pharyngeal stimulus [1] . These responses are transient but in patients with cardiovascular compromise and disorders like intracranial aneurysm even these small and temporary changes may result in damaging effects [2] . Various pharmacological agents which include opioids [3] , calcium channel blockers, β -blockers, Clonidine [4] have been tried by several researchers for diminishing this hemodynamic response Dexmedetomidine a newer α 2agonist have also been used for attenuating the sympathetic response. Dexmedetomidine shows a high ratio of specificity for the α 2 receptor (α 2/α 1 1600:1) compared with Clonidine (α 2/α 1 200:1), leading to sympatholytic effect and blunting of the exaggerated hemodynamic responses [5] . Dexmedetomidine also gives additional benefit by its other actions like sedation, analgesia, anxiolysis, improved hemodynamic stability with decrease in requirement of Anaesthetics i.e. up to 90% decrease in minimum alveolar concentration (MAC) of volatile Anaesthetics [6] . There are several studies which have used number of doses of dexmedetomidine for attenuation of hemodynamic response to laryngoscopy and intubation but particular dose is still not been recommended. We have come across very few studies comparing 1 μg/kg body weight and 0.5 μg/kg weight. Dexmedetomidine. Hence, we decided to compare these two doses for attenuation