1 Health-Related Quality of Life in the Spironolactone to Reduce ICD Therapy (SPIRIT) Trial Running Title: HRQOL in SPIRIT Ana Carolina Sauer Liberato RN, PhD 1 Visiting Faculty, University of Freiburg ORCID: 0000-0002-4046-5553 Merritt H. Raitt, MD 2,3 Chief Cardiology Section, VA Portland Health Care System Professor, Knight Cardiovascular Institute ORCID: 0000-0001-5638-7732 Ignatius GE Zarraga, MD 2,3 Attending Physician, VA Portland Health Care System Assistant Professor, Knight Cardiovascular Institute Karen S. MacMurdy, MD 2,3 Attending Physician, VA Portland Health Care System Assistant Professor, Knight Cardiovascular Institute Cynthia M. Dougherty ARNP, PhD, FAAN, FAHA 4,5 Professor, University of Washington School of Nursing Nurse Practitioner, VA Puget Health Care System- Seattle ORCID: 0000-0002-6492-1365 1. Institute of Nursing, University of Freiburg, Germany. 2. VA Portland Health Care System, Division of Cardiology, Portland, OR 3. Knight Cardiovascular Institute, Oregon Health and Sciences University, Portland OR 4. University of Washington School of Nursing, Department of Biobehavioral Nursing and Health Informatics, Seattle, WA 5. VA Puget Sound Health Care System, Seattle, WA Corresponding Author : Cynthia M. Dougherty ARNP, PhD All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted September 1, 2020. ; https://doi.org/10.1101/2020.08.27.20016378 doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.