Int. J. Pharm. Investigation, 2021;11(2):225-229 225 International Journal of Pharmaceutical Investigation, Vol 11, Issue 2, Apr-Jun, 2021 Original Article Formulation Development of Celecoxib Loaded Microsponges using Eudragit and Ethyl Cellulose Vishwajeet Swami 1,2, *, Amir A Shaikh 2 , Pooja N Jadhav 3 , Rahul S Buchade 2 1 Dr. D.Y. Patil Institute of Pharmaceutical sciences and Research, Pimpri, Pune, Maharashtra, INDIA. 2 SCES’s Indira College of Phamacy, Tathwade, Pune, Maharashtra, INDIA. 3 CAYMET’s Siddhant College of Pharmacy, Sudumbare, Pune, Maharashtra, INDIA. ABSTRACT Background: Microsponge is a class of dosage form containing porous nature containing drug that is targeted to achieve sustained action for prolong period. Microsponge based delivery system results in drug localization on skin surface and in epidermis without moving in systemic circulation to higher extent. Methods: Present study aims to formulate the microsponge containing celecoxib by quasi emulsification solvent diffusion method. Prepared formulations were evaluated for particle size, % entrapment efficiency, production yield, surface morphology, etc. Results: Formulation F1 and E2 were considered as optimized formulation having drug loading 91±4.2 % and 91±3.1 % respectively. FTIR spectroscopy analysis indicated the chemically stable, crystalline nature of the drug in these microsponges. Small change in crystallinity of pure drug was observed in XRD study. SEM study shows good microsponge surface appearance with pores on surfaces. Average particle size of optimized microsponge formulation F1 is found to be 48 µm while E2 formulation gave microsponges with particle size of 33.7 µm. As the RPM was increased the microsponge’s size was also decreased and formed microsponges were spherical and is having uniform nature. Conclusion: Finally it can be concluded that chemically stable, uniform and porous microspheres were formed using Eudragit L-100 and Ethyl cellulose. Key words: Celecoxib, Quasi emulsification, Eudragit, Ethyl cellulose. Correspondence Mr. Vishwajeet Swami Dr. DY Patil Institute of Pharmaceutical sciences and research, Pune, Maharashtra-411018, INDIA. Email: amirshaikhamu@gmail.com DOI: 10.5530/ijpi.2021.2.40 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. INTRODUCTION Topical drug delivery defined as application dosage form containing API effectively to skin for treatment of topical disorders. 1 Microsponge is polymeric drug delivery system containing porous microspheres basically used for topical administration of large no of active pharmaceutical ingredients such as antifungal, anti-infective and inflammatory agents. 2 Drugs administered through microsponge has significant advantages such as dose reduction, stability enhancement, lesser side effects, and most prominently modified drug release profile. 3 Loading of a drug into microsponge takes place by two processes. First is liquid-liquid suspension polymerization and the second one is quasi emulsion solvent diffusion method. In the second method, the microsponge was prepared by using different concentrations of polymers. 4 In allergic and inflammatory diseases mycology infections play an important role. ere is some treatment is available for fungal infections. ese infections prominently detected and spread in countries whose health system in poor and mainly in bellow poor countries having low income. 5 Celecoxib is a class II drug produces irritation when taken internally so it is necessary to make formulation that gives sustained action when applied locally. Direct contact of celecoxib with the skin is avoided to reduced skin irritation, Current research work oriented towards design and characterization of celecoxib microsponge to improve release characteristics of celecoxib aſter entrapment into microsponges as well as to improve localized delivery of celecoxib to the skin which reduces systemic absorption. MATERIALS AND METHODS Materials Celecoxib was provided by Lupin Research Park, Pune, India. Eudragit L-100, Ethyl cellulose, Ethyl cellulose and Carbapol 940 were obtained Analab Fine Chemicals, Mumbai, India. All other reagents and chemicals were of analytical grade. Methods Design Expert V10 soſtware was used for formulation development. A CCD with α=1 was employed as per standard protocol. 6 e concentration of polymers and RPM were selected as experimental factors. All other ingredients and variables were kept constant for the study. irteen runs with various combinations of factors were obtained by design expert soſtware as depicted in Table 1. Preparation of standard calibration curve of celecoxib in Phosphate buffer pH 6.8 e UV spectrum of Celecoxib was obtained using UV spectrophotometer. Weighed 10 mg of pure drug was dissolved in the 10ml Phosphate buffer to make a concentration of 1000 µg/ml (Stock-I). From the stock-I, 1 ml of aliquot was withdrawn and transferred to a 100ml volumetric flask and made up the volume with Phosphate buffer to obtain a concentration of 10µg/ml (Stock-II). From the stock solution- II aliquots of 0.2ml, 0.4ml, 0.6ml, 0.8ml, 0.10ml, 0.12ml were withdrawn and transferred into10ml volumetric flask and made up the volume with buffer to obtain a concentration of 2µg/ml, 4µg/ml, 6 µg/ml, 8 µg/ml, 10 µg/ml,12 µg/ml,14 µg/ml respectively. e absorbance of solutions were