_____________________________________________________________________________________________________ *Corresponding author: Email: benjamintakyi1997@gmail.com; Cite as: Takyi, Benjamin. 2024. “Acquisition and Application of 21st Century Skills Among Pre-Service Social Studies Teachers in Ghana”. Asian Journal of Education and Social Studies 50 (11):335-48. https://doi.org/10.9734/ajess/2024/v50i111658. Asian Journal of Education and Social Studies Volume 50, Issue 11, Page 335-348, 2024; Article no.AJESS.127008 ISSN: 2581-6268 Acquisition and Application of 21 st Century Skills among Pre-service Social Studies Teachers in Ghana Benjamin Takyi a* a Department of Social Studies Education, Faculty of Social Sciences Education, University of Education Winneba, Ghana. Author’s contribution The sole author designed, analysed, interpreted and prepared the manuscript. Article Information DOI: https://doi.org/10.9734/ajess/2024/v50i111658 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/127008 Received: 12/09/2024 Accepted: 15/11/2024 Published: 28/11/2024 ABSTRACT It is widely acknowledged that Social Studies can aid students in acquiring essential 21st-century skills. Nonetheless, research on the real-world application of these skills is limited. While some studies have looked at integrating these skills into the Social Studies curriculum and teaching approaches, they have not investigated their use in practical situations. This study aimed to examine how pre-service Social Studies students at the University of Education, Winneba, in Ghana acquire and apply 21st-century skills. A quantitative approach was used with a descriptive survey design. The study included a population of 333 pre-service Social Studies teachers from the Department of Social Studies Education. The respondents were selected through proportionate stratified sampling, and data was gathered using a structured questionnaire. Descriptive statistics and a one-sample t-test were used to analyze the data. The results showed a low level of 21st- century skills acquisition among the respondents, with a mean of mean score of 1.9 (SD = 0.9). The one-sample t-test revealed significant findings across all assessed 21st-century skills, with mean Original Research Article