Case Report Volume 8 • Issue 4 357 Cardiac Metastases from Mucosal Head and Neck Squamous Cell Carcinoma Courtney B Shires 1* , Karuna Dewan 2 , Allen Ardestani 1 Affiliation: 1 West Cancer Center & Research Institute, Germantown, TN, USA. 2 Division of Laryngology, Otolaryngology Head and Neck Surgery, Louisiana State University, Shreveport, LA, USA. *Corresponding author: Courtney Shires, MD 7945 Wolf River Blvd Germantown, TN 38138 West Cancer Center & Research Institute, Germantown, TN, USA. Citation: Courtney B Shires, Karuna Dewan, Allen Ardestani. Cardiac Metastases from Mucosal Head and Neck Squamous Cell Carcinoma. Journal of Cancer Science and Clinical Therapeutics. 8 (2024): 357-362. Received: December 09, 2024 Accepted: December 16, 2024 Published: December 26, 2024 Abstract Objectives: To understand that cardiac metastasis of mucosal head and neck squamous cell carcinoma (SCCa) is rare and carries a poor prognosis. To acknowledge the possibility of cardiac metastasis in patients with mucosal head and neck SCCa. This condition is usually asymptomatic, but it can present with EKG changes, syncope, or even sudden death. Methods: A single case report of a 55-year-old female with a history of T2N1M0 oral tongue SCCa treated with surgery and postoperative radiation is presented. The patient went on to develop a cardiac septal metastasis. To date, fewer than 35 documented cases of mucosal head and neck SCCa metastasizing to the heart are present within the literature. This is an uncommon but life-threatening condition. Results: In our case, the patient was placed on hospice and passed away in her home 11 months later. A literature review over 35 years (1985-2020) of the incidence, presentation, diagnosis, treatment, and outcome of patients with Head and Neck Mucosal Squamous Cell Carcinoma (HNMSCC) and cardiac metastasis (CM) was performed. CM of HNMSCC occurs on rare occasion, with 33 other documented cases. The most common primary tumor sites were oral tongue (33.3%), and larynx (27.8%). The most common presenting symptoms were dyspnea (16.7%) and chest pain (16.7%). Conclusions: Cardiac metastasis is uncommon but life-threatening long- term sequelae of mucosal head and neck SCCa without any effective treatment options. Keywords: Cardiac metastasis; Head and neck cancer; Squamous cell carcinoma. Introduction Cardiac metastasis (CM) of mucosal head and neck squamous cell carcinoma is an incredibly rare but universally fatal phenomenon. The incidence of cardiac metastasis of all squamous cell carcinoma has been found to be between 5 and 10 percent when examining autopsies. The incidence of cardiac metastases is substantially higher in malignancies from other sites such as melanoma, lung, breast, esophagus, and lymphoma. There are 12 reported cases of cardiac metastasis from squamous cell carcinoma of the tongue in the English-language medical literature [1-6]. There are 34 cases of cardiac metastasis (CM) from multiple locations of mucosal head and neck squamous cell carcinoma (HNMSCC) [2-18]. When distant metastases of HNMSCC occur, they most often involve the lung, skin, liver or bone. The mechanism of metastasis from the head and neck to the myocardium is poorly understood. Pathways that have been proposed are hematogenous