INTRODUCTION Heterocyclic compounds are pharmacologically and medicinally very important because most of the drugs present in the market today are containing heterocyclic scaffolds. Benzoxazole derivatives exhibits anthelmintic 1 , antiulcer 2 , antitumor 3 , antimicrobial 4,5 andanticancer 6 activities. Benzoxazole containing compounds are also acts as RSK2 inhibitor 7 and  1 -AR antagonist 8 . Thiazole scaffold containing compounds are associated with anti-inflammatory 9 , ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org An International Open Free Access, Peer Reviewed Research Journal ISSN: 0970-020 X CODEN: OJCHEG 2015, Vol. 31, No. (1): Pg. 431-433 Synthesis and Characterization of Novel Thiazole Anchored Pyrazolyl Benzoxazoles H. N. AKOLKAR and B. K. KARALE* Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar - 414001, India. *Corresponding author Email: bkkarale@yahoo.com http://dx.doi.org/10.13005/ojc/310151 (Received: January 03, 2015; Accepted: February 06, 2015) ABSTRACT 3-Formylchromone 1 was treated with 1-(4-(4-bromophenyl)thiazol-2-yl)hydrazine 2 to get (1-(4-(4-bromophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)(2-hydroxyphenyl)methanone --------(3a- e). Compound 3 on treatment with NH 2 OH/HCl gavethe compound 2-[(E)-{1-[4-(4-bromophenyl)- 1,3-thiazol-2-yl]-1H-pyrazol-4-yl}(hydroxyimino)methyl]phenol (4a-e). Compound 4 on treatment with POCl 3 gave 2-(1-(4-(4-bromophenyl)thiazol-2-yl)-1H-pyrazol-4-yl)benzo[d]oxazole (5a-e). The synthesized compounds have been characterized with the help of spectral techniques. Key words: Benzo[d]oxazole, Thiazole, Pyrazole, 3-Formylchromone. cyclooxygenase-2 inhibitor 10 , analgesic 11 , monoamine oxidases 12 and immunosuppressive 13 activities. Pyrazole is one of the most important pharmacologically active heterocyclic compound. Pyrazole and its derivatives are associated with fungicidal 14 , anti-angiogenic 15 , antidiabetic 16 , antiparasitic 17 , antitubercular 18 , antimicrobial 19 and antioxidant 19 activities. 3-Formylchromoneis one of the class of chromone family. Chromone derivatives are known to have acetylcholinesterase inhibitor 20 ,antitumor 21 , breast cancer resistance protein ABCG2 inhibition 22 activities.