LRC02 Clinical Pharmacokinetics - Video tape - Abstracts of Learning Resource Centre Mangues MA, Farr6 R, Bonal J Pharmacy Department. Hospital Sant Pan. 08025 Barcelona. Spain. This video on Clinical Pharmacokinetics, is part of the in-service training programme for Hospital Pharmacists coordinated by the Spanish Society of Hospital Pharmacists (SEFH). It has been carried out with the logistic and technical support of Lilly Laboratories. In recent years, many hospital pharmacists have become involved in the practice of Clinical Pharmacokinetics. This has been fundamental in its becoming yet another diagnostic and therapeutic procedure on which many hospitals reiD The video is intended for those professionals who are interested in getting involved in this field and will attempt to give a general vision of Clinical Pharmacoldnetics. Two subjects are treated. First of all, the clinical benefits to be obtained from the practical application of PharmacoMnetics and secondly those organizational aspects which, after some years of experience, we consider most important with a view to achieving such benefits. LRC01 - LRC1 6 LRC01 TDMSIFO - A PHARMACOKINETIC PROGRAM FOR LEAST-SQUARES AND BAYESIAN ANALYSIS OF REPEATED-DOSE PHARMACOKINETIC CURVES. C.Pistolesi* A.Messori A microcomputer program is presented which analyses multiple-dose pharmacokinetic curves using either a least-squares nonlinear analysis or a bayesian fit. The least-squares subroutine is based on the Gauss-Newton algorithm (1-2) and is designed to fit retrospective pharmacokinetic curves. This subroutine can also generate the so-called population pharmacokinetic parameters of a drug using the Standard Two-Stage method (3). The bayesian subroutine can instead be used to individualise prospectively the dosage regimen of a patient based on the concentrations measured in the initial phases of the treatment. All the pharmacokinetic subroutines of the program use the one-compartment model with either constant-rate intravenous infusion or oral route with zero-order absorption. The program was tested in a series of i0 bone marrow transplantion patients treated with cyclosporine. The least-squares estimates of the one-compartment parameters, calculated by the program, were compared with those generated by the SIMKIN program (simkin Inc, Gainesville, USA). References 1. Messori A, Donati-Cori G, Tendi E. Iterative least- squares fitting programs in pharmacokinetics for a programmable hand-held calculator. Am J HOSD Pharm. 1983;40:1673-1684. 2. Ruffo S, Messori A, Grasela TH, Longo G, Donati-Cori G, Matucci M, Morfini M, Tendi E. A calculator program for clinical application of the Bayesian method of predicting plasma drug levels. COmDUt Pro~r Biomed 1985;19:167-177. 3. Ruffo S, Messori A, Donati-Cori G, et al. Calculator programs for weighted least-squares nonlinear regression analysis in pharmacokinetics. Am J Hosp Pha~ 1985;42:628. LRC03 REGIONAL AUTOMATED DATA BASES AND POST-MARKETING SURVEILLANCE STUDIES IN A LARGE COHORT OF POPULATION. *M.G. Troncon *, C. Cattaruzzi ^, G. Simon ^^. Direzione Regionale delia SanitY. Regione Friuli - Venezia Giulia. The SIRS (Regional Medical Information System) is located in Fnuli - Venezia Giulia which is a region in North East Italy. It has maintained complete and accurate records of clinical outcomes since 1979 and drug prescriptions since 1991 for the 1.2 million inhabitants of the region. These data bases give information about hospitalization records and discharge diagnoses (ICD IXth Revision), these include birth and death registration files of all the residents covered by the National Italian Health System. Pharmacy prescription data base provides chronologic prescription profiles of patients and the exposure to drugs is automatically calculated in DDD/1000 inhabitants I per day. Each inhabitant receives a individual identification code (CRA) which is the key present in each medical file and allows every record of all the data bases to be linked. The SIRS system can offer an efficient method of identifying patients with particular diseases by linking prescription records with individual clinical patients' files. It also enables cohort studies to be carried out, identifying people taking a particular drug and monitoring these patients in order to detect any medical event. It may also be used to monitor tracers in order to estimate the prevalence of some chronic diseases in the population. SIRS is a computer based system useful in carrying out inexpensive post - marketing surveillance studies on a very large population similar to that in operation in others countries (U.K., Saskatchewan, Compass, etc.). Area SIFO di Farmacocinetica, c/o Pharmaceutical Service, Borgo Roma University Hospital, Verona, Italy. * Servizio Farmaceutico, Dir.Reg Sanita, Trieste (Italy); USL n~ Udine (Italy) ^ Settore Farmaceutico, USL n~ Udine (Italy) '~ Ufficio Epidemiologico, USL n ~ 9, S. Vito al Tagliamento (Italy) G ] 4 Pharmacy World ~F Science