Middle-East Journal of Scientific Research 12 (8): 1107-1110, 2012 ISSN 1990-9233 © IDOSI Publications, 2012 DOI: 10.5829/idosi.mejsr.2012.12.8.7133 Corresponding Author: Reza Hassanzadeh Makoui, Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran. 1107 Evaluation of Serum Value of Magnesium in Patients with Acute Coronary Syndrome (ACS) and its Relationship with Occurrence of Arrhythmias Reza Hassanzadeh Makoui Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran Abstract: This study was designed to assess the association between arrhythmias and serum Mg level in patients with acute coronary syndrome. Our study was cross-sectional one. In this study, we measured serum Mg level in first 24h of admission in 182 patients with acute coronary syndrome. The mean age of patients was 64.5 years. The frequency of sex male was more than female (54.9%). Results of serum magnesium values showed that 43 cases (23.6%) were suffering from hypomagnesaemia and 139 cases (76.4%) were with normal magnesium level. The prevalence of arrhythmias among our study group was as follows: 54.4% with no arrhythmias and 45.6% with arrhythmias. Among 43 patients with hypomagnesaemia 23 cases had arrhythmia and 20 cases had not. From other side, in patients with normal magnesium level 60 cases (43.2%) had arrhythmia and 79 cases (56.8%) had not. In this study there was no significant association between serum Mg levels with occurrence of arrhythmias in patients with acute coronary syndrome. Key words: Serum Magnesium ACS Arrhythmia Heart. INTRODUCTION In the absence of ST segment elevation (non-ST The definition of acute coronary syndrome initially managed without emergency reperfusion therapy. depends on the specific characteristics of each Magnesium (Mg) has a very important role in element of the triad of clinical presentation (including proper functioning of the human body, especially the a history of coronary artery disease), electrocardiographic cardiovascular system. Magnesium deficiency in the body changes and biochemical cardiac markers. An acute is associated with different risk factors for cardiovascular coronary syndrome may occasionally occur in the diseases and atherogenesis such as increasing oxidative absence of electrocardiographic changes or elevations in stress, cytokine synthesis, nitrogen oxides and mediators biochemical markers, when the diagnosis is supported by of inflammation and adhesion molecules on micro vascular the presence of prior documented coronary artery disease endothelial cells [2, 3]. It was proven that 6.9 - 11% of or subsequent confirmatory investigations [1]. hospitalized patients with acute myocardial infarction and The immediate management of a patient with an 65% of patients in intensive care units have a lack of Mg acute coronary syndrome is determined by the [4, 5]. A possible role of magnesium in the etiology of characteristics of the presenting electrocardiogram and ischemic heart disease is still not sufficiently clear and it in particular, the presence or absence of ST segment is likely that several mechanisms are involved. Previous elevation. In combination with the clinical studies have demonstrated that increased intake of presentation, an ST segment elevation acute coronary dietary magnesium may lower blood triglyceride level and syndrome (acute ST elevation MI) is defined by the increase high-density lipoprotein (HDL) cholesterol levels presence of 1 mm ST elevation in at least two adjacent [6]. The main objective of present study was to evaluate limb leads, 2 mm ST elevation in at least two contiguous serum value of magnesium in patients with acute coronary precordial leads, or new onset left bundle branch block. syndrome and its relationship with occurrence of These patients are initially managed with emergency arrhythmias in these patients hospitalized in CCU section reperfusion therapy [1]. of Vali-e-asr hospital of Zanjan, Iran during 2006-2010. segment elevation acute coronary syndrome); patients are