European Journal of Therapeutics pISSN: 2564-7784 eISSN: 2564-7040 Eur J Ther. 2024;30(3):400-408. https://doi.org/10.58600/eurjther2034 Review Article 400 Correspondence Bernardo Correia Lima Address: Dental School of University of São Paulo - Av. Prof. Lineu Prestes, 2227. Cidade Universitária, São Paulo- SP-Brazil. 05508-000 E-mail: bernardoclima@usp.br This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Received: 2024-01-27 Accepted: 2024-03-27 Published Online: 2024-03-29 Optimizing Patient Outcomes in Orthognathic Surgery: A Proposed Nutritional Protocol for Weight Loss Control and Bone Formation Bernardo Correia Lima 1,2 * , Ricardo Grillo 3,4 , Bruno Alvarez Quinta Reis 5 , Leonardo Augustus Peral Ferreira Pinto 6,7 , Fernando Melhem-Elias 3,5 1 Department of Oral Diagnosis, Dental Radiology and Imaginology, Dental School of University of São Paulo, São Paulo – SP, Brazil 2 Departament of Oral Surgery and Diagnosis, Hospital da Boca, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro – RJ, Brazil 3 Department of Oral and Maxillofacial Surgery, Traumatology and Prosthesis, Dental School of University of São Paulo, São Paulo - SP, Brazil 4 Departament of Oral and Maxillofacial Surgery, Faculdade Patos de Minas, Brasília - DF, Brazil 5 Private Practice in Oral and Maxillofacial Surgery, São Paulo - SP, Brazil 6 Oral and Maxillofacial Surgery Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro - RJ, Brazil 7 Private Practice in Oral and Maxillofacial Surgery, Rio de Janeiro - RJ, Brazil ABSTRACT Objective: The primary objective of this research was to conduct a comprehensive literature review, offering an in-depth examination of the nutritional considerations associated with orthognathic surgery and suggest a perioperative nutritional protocol for enhanced recovery. Methods: To achieve this objective, the authors rigorously examined existing literature while adhering to the guidelines outlined in PRISMA-ScR. The scope of eligible studies encompassed various types, with the exclusion of case reports and reviews. The research applied specific inclusion criteria, concentrating on the nutritional aspects relevant to perioperative and/or postoperative phases of major maxillofacial surgery. Results: A total of 39 articles were identified that met the screening criteria. These articles were then used to generate a discussion and propose a protocol aimed at reducing body weight loss following major maxillofacial surgery and improving bone formation post-osteotomies. Conclusions: While the realm of maxillofacial surgery sees significant advancements in other fields, there exists a noticeable gap in addressing the nutritional status of surgical patients. This oversight can potentially lead to suboptimal postoperative outcomes. Recognizing the pivotal role of nutrition in enhancing surgical results, this paper emphasizes the importance of maintaining optimal nutritional status among orthognathic surgery patients. Keywords: Maxillofacial surgery; maxillofacial surgical procedures; treatment outcome; dietary supplements © 2024, European Journal of Therapeutics, Gaziantep University School of Medicine.