Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol (Preparation and Characterization of Fluconazole- Resorcinol Co-crystal) FIKRI ALATAS 1* , HESTIARY RATIH 1 , TITTA HARTYANA SUTARNA 1 , YOGA WINDU WARDHANA 2 , DINI TERESLINA 1 , & SUNDANI NURONO SOEWANDHI 3 1 Kelompok Keahlian Farmasetika, Fakultas Farmasi, Universitas Jenderal Achmad Yani, Jl. Terusan Jenderal Sudirman, Cimahi, Indonesia, 40521. 2 Fakultas Farmasi, Universitas Padjadjaran, Jl. Raya Jatinangor, Sumedang, Indonesia. 3 Sekolah Farmasi, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung, Indonesia. Diterima 14 Oktober 2019, Disetujui 25 September 2020 Vol. 18, No. 2 JURNAL ILMU KEFARMASIAN INDONESIA, Oktober 2020, hlm. 177-183 ISSN:1693-1831, E-ISSN: 2614-6495 *Penulis korespondensi Email: fikri.alatas@lecture.unjani.ac.id Abstract: Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis and candidiasis, is known to have low bioavailability due to its low solubility. The purpose of this study was to prepare and characterize co-crystal fluconazole-resoscinol (FLU-RES). The preparation of co-crystal was performed by grinding together the equimolar mixture of FLU-RES which is dripped with a few ethanol. Powder X-ray diffraction, differential scanning calorimetry (DSC), and polarized microscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevant physicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and 6.8 buffer solution. The powder X-ray diffractogram of FLU-RES milled result showed the presence of new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result by DSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES. The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while its dissolution rate is 1.67-1.72 times faster than pure FLU. Keywords: fluconazole, resorcinol, solubility, co-crystal, powder X-ray diffraction. Abstrak: Flukonazol (FLU), suatu anti jamur oral yang banyak digunakan pada pengobatan vaginitis dan kandidiasis diketahui memiliki bioavailabilitas kecil karena kelarutaanya rendah. Tujuan penelitian ini adalah untuk membuat dan mengkarakterisasi ko-kristal flukonazol-resorsinol (FLU-RES). Penyiapan ko-kristal dilakukan menggerus bersamaan campuran ekuimolar FLU-RES yang diteteskan sedikit etanol. Metode difraksi sinar-X serbuk, differential scanning calorimetry (DSC), dan mikroskop polarisasi dilakukan untuk mengkarakterisasi pembentukan ko-kristal FLU-RES. Pengujan sifat fisikokimia meliputi uji kelarutan di dalam air dan uji disolusi dalam larutan dapar pH 1,2; 4,5 dan 6,8. Difraktogram sinar-X serbuk hasil penggilingan FLU-RES menunjukkan keberadaan puncak-puncak baru dan hilangnya puncak-puncak utama FLU dan RES. Karakterisasi dengan DSC dan mikroskop polarisasi juga mennujukkan adanya pembentukan ko-kristal antara FLU-RES. Kelarutan ko-kristal FLU-RES dalam air dua kali lebih tinggi dibandingkan dengan FLU murni, sementara laju disolusinya 1,67-1,72 kali lebih cepat daripada FLU murni. Kata kunci: flukonazol, resorsinol, kelarutan, ko-kristal, difraksi sinar-X serbuk.