33 January 2025, Volume 13, Number 1 Pouyan Ahanian Moghaddam 1 , Seyed Hamid Atashpour 1* , Mohsen Golparvar 1 1. Department of Counseling, Faculty of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. * Corresponding Author: Seyed Hamid Atashpour, Associate Professor. Address: Department of Psychology, Faculty of Educational Sciences and Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. Tel: +98 (913) 1068707 E-mail: hamidatashpour@gmail.com Objective: This study aims to compare the effectiveness of integrated schema therapy and mindfulness-based intervention with schema therapy and cognitive behavioral therapy (CBT) on the psychological flexibility of women exhibiting obsessive-compulsive symptoms. Methods: The study used a quasi-experimental pre-test-post-test design with control and follow- up groups. The research was conducted on women with obsessive disorder who were referred to the Nedaye Agahi and Zehne Pouya Clinic in Tehran City, Iran, during the fall and winter of 2021. A total of 60 participants were selected using a convenience sampling method and were randomly assigned to three intervention groups: An integrated schema therapy and mindfulness- based intervention group, a schema therapy group, a CBT group and one control group. Data were collected using the psychological flexibility questionnaire and the Yale-Brown obsessive- compulsive scale. A repeated measures analysis of variance was conducted using SPSS software. Results: The results revealed significant differences among all three treatment groups compared to the control. In particular, the integrated interventions of schema therapy and mindfulness, as well as schema therapy and cognitive behavioral therapy, demonstrated a significant effect on psychological flexibility scores (P<0.05) compared to the control group. However, the two- way comparisons for other differences were not significant (P>0.05). Conclusion: Given the emotional and cognitive challenges faced by patients with obsessive disorders, it is essential to prioritize these aspects in the treatment process. A B S T R A C T Article info: Received: 16 Aug 2024 Accepted: 10 Nov 2024 Available Online: 01 Jan 2025 Keywords: Psychological flexibility, Schema therapy, Mindfulness, Cognitive behavioral therapy (CBT), Obsession Research Paper Comparing the Effectiveness of Combined Schema Therapy and Mindfulness With Schema Therapy and CBT on Psychological Flexibility Citation Ahanian Moghaddam, P., Atashpour, SH., & Golparvar, M. (2025). Comparing the effectiveness of combined schema therapy and mindfulness with Schema Therapy and CBT on Psychological Flexibility. Journal of Practice in Clinical Psychology, 13(1), 33-46. https://doi.org/10.32598/jpcp.13.1.981.1 https://doi.org/10.32598/jpcp.13.1.981.1 Use your device to scan and read the article online Copyright © 2025 The Author(s); This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC: https://creativecommons.org/licenses/by-nc/4.0/legalcode.en), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.