Journal Pre-proofs Vitamin K 3 chloroderivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis and inhibits aggresome formation in hepatocellular carcinoma cells Mona Dawood, Mohamed-Elamir F. Hegazy, Mohamed Elbadawi, Edmond Fleischer, Anette Klinger, Gerhard Bringmann, Claudia Kuntner, Letian Shan, Thomas Efferth PII: S0006-2952(20)30412-3 DOI: https://doi.org/10.1016/j.bcp.2020.114176 Reference: BCP 114176 To appear in: Biochemical Pharmacology Received Date: 10 April 2020 Revised Date: 21 July 2020 Accepted Date: 22 July 2020 Please cite this article as: M. Dawood, M.F. Hegazy, M. Elbadawi, E. Fleischer, A. Klinger, G. Bringmann, C. Kuntner, L. Shan, T. Efferth, Vitamin K 3 chloroderivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis and inhibits aggresome formation in hepatocellular carcinoma cells, Biochemical Pharmacology (2020), doi: https://doi.org/10.1016/j.bcp.2020.114176 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Inc.