693| International Journal of Pharmaceutical Research | Jan - March 2020 | Vol 12 | Issue 1 Research Article Synthesis and biological evaluation of Schiff bases and pyrazole derivatives derive from chalcones, (2E)- 1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one ALI H. HASSAN 1 , HAMID H. MOHAMMED 1* 1 Department of Chemistry, College of Science, Mustansiriya University, Baghdad, Iraq * Corresponding author: E-mail:hamidhashim@uomustansiriyah.edu.iq hammed_sugar@yahoo.com Received: 18.11.19, Revised: 21.12.19, Accepted: 07.01.20 ABSTRACT This work describes the synthesis of Schiff bases (2-8), pyrazoles and (9-18) derivatives from chalcones (1), (2E)-1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one, and some biological studies of these compounds against (gram +ve) bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and (gram –ve) bacteria (Escherichia coli and Klebsiellapneumniae); and antifungal actioncontra (Candida albicans) .Series of biologically active substituted Schiff bases(2-8) were synthesized from chalcone (1) and different substituted aldehyde compounds in the presence of piperidine as catalysis and ethanol as a solvent.Some of Schiff bases compounds on reaction with phenylhydrazine or hydrazinehydrate in ethanol as a solvent give pyrazole derivative (9-18). The homogeneity of all the newly synthesized compounds has been checked by TLC. The chemical structures of the newly synthesized compounds were confirmed by FTIR, 1 HNMR spectroscopic analysis, and the data are in accord with the assigned structure. Keywords: chalcone, Chiff bases, pyrazole, biological evaluation INTRODUCTION Chalcones are forerunner mixes for flavonoids biosynthesis for plants. Chalcones have a wide range of organic activity. [1] Schiff bases are without a doubt the most for the most part used common blends. They are used such shades and hues, catalyst, inter- mediates natural synthesis, such polymer offset [2] . The Schiff bases have gotten significant consideration as a result of their intriguing physical and synthetic properties, association in organically significant responses and far reaching use of their metal compounds [3] . Schiff's bases are used in the photo stabilization of poly (vinyl chloride) polymers against photo degradationbyultra- violateradiation [4] , Antioxidantactivity [5] , Antibacterialactivity [6] Fungistatic activity [7] , Antiviralactivity [8] , antimicrobial and anthelmintic activities (I) [9] Pyrazole core has articulated pharmacological applications such hostile to anxiety [10,11] antipyretic, pain relieving with mitigating drugs. [12-14] sure alkyl pyrazolesdisplay critical bacteriostatic, bactericidal and fungicidal actions [15] . EXPERIMENTAL Chemical materials The reactants with solvents utilized in this investigation were reagents evaluation and they are accessible from Sigma‐Aldrich and Fluka organizations. Melting point is resolved in slim tube in a Germany, Stuarts, SMP30 Melting point contraption and are uncorrected. Infrared spectra (FT-IR) were registered using by SHIMADZU FT- IR8400S spectrophotometer at the Department of Chemistry/College of Science/ University of Mustansiriyah. 1 HNMR spectra were recorded on