Basic and Clinical 745 November & December 2024, Vol 15, No. 6 Research Paper Bihemispheric tDCS Improves Memory and Alters EEG Parameters in Patients With Mild Cognitive Impairment Soroush Ahmadi Machiani 1 , Sajjad Rezaei 2 , Alia Saberi 3 , Arman Keymoradzadeh 1 , Babak Bakhshayesh 1 , Kambiz Rohampour 1* 1. Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. 2. Department of Psychology, Faculty of Literature and Humanities, University of Guilan, Rasht, Iran. 3. Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. * Corresponding Author: Kambiz Rohampour, Associate Professor. Address: Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. E-mail: rohampour@gmail.com Introduction: Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia. Bihemispheric transcranial direct current stimulation (tDCS) modulates cortical excitability and interhemispheric interaction. The dorsolateral prefrontal cortex (DLPFC) is involved in executive control and working memory. The present study investigates whether stimulating the left DLPFC while suppressing the right DLPFC can influence brain waves and cognitive abilities in patients with MCI. Methods: A total of 36 MCI patients were randomly allocated into active and sham tDCS groups. Ten sessions of active or sham tDCS were applied. The anode electrode was placed on the left DLPFC (F3) and the cathode on the right (F4). Memory assessment was performed using the Wechsler memory scale-revised (WMS-R) before, immediately after, and three months after the intervention. Resting-state electroencephalography (EEG) was performed before and immediately after tDCS. The absolute and relative powers of different frequency bands and the coherence between electrodes were calculated using the NeuroGuide software, version 3.2.4. Results: Active tDCS improved the memory quotient and all WMS-R subscales in MCI patients immediately and three months after tDCS application (P<0.01). The absolute power of the delta band and the relative power of the delta and theta bands reduced significantly (P<0.05). The relative alpha band power and frontotemporal coherence were increased. A frontal asymmetry was also detected after active tDCS. Conclusion: Bihemispheric tDCS of the DLPFC leads to sustained cognitive improvements and beneficial changes in brain activity in MCI patients, suggesting its potential as an effective therapeutic intervention. Article info: Received: 16 Feb 2024 First Revision: 27 Jul 2024 Accepted: 29 Jul 2024 Available Online: 01 Nov 2024 Keywords: Mild cognitive impairment (MCI), Electroencephalography (EEG), Transcranial direct current stimulation (tDCS), Wechsler memory scale, Coherence Citation Ahmadi Machiani, S., Rezaei, S., Saberi, A., Keymoradzadeh, A., Bakhshayesh, B., & Rohampour, K. (2024). Bihemispheric tDCS Improves Memory and Alters EEG Parameters in Patients With Mild Cognitive Impairment. Basic and Clinical Neuroscience, 15(6), 745-758. http://dx.doi.org/10.32598/bcn.2024.514.2 http://dx.doi.org/10.32598/bcn.2024.514.2 Use your device to scan and read the article online A B S T R A C T Copyright © 2024 The Author(s); This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC: https://creativecommons.org/licenses/by-nc/4.0/legalcode.en), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.