Gene Section Short Communication Atlas Genet Cytogenet Oncol Haematol. 2012; 16(12) 898 INIST-CNRS OPEN ACCESS JOURNAL Atlas of Genetics and Cytogenetics in Oncology and Haematology MAP2K4 (mitogen-activated protein kinase kinase 4) Kentaro Nakayama, Naomi Nakayama, Kohji Miyazaki Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan (KN, NN, KM) Published in Atlas Database: June 2012 Online updated version : http://AtlasGeneticsOncology.org/Genes/MAP2K4ID244ch17p12.html DOI: 10.4267/2042/48361 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Other names: JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1 HGNC (Hugo): MAP2K4 Location: 17p12 Note Total length: 122917 bp. Strand: plus. DNA/RNA Note Mitogen-activated protein kinase kinase 4 (MKK4) was first identified in a cDNA library from Xenopus laevis embryos using a PCR-based screen and was initially referred to as XMEK2 (Yashar et al., 1993). Drosophila, mouse, rat, and human homologues were subsequently cloned. MKK4 is also known as stress- activated protein kinase/extracellular signal-related protein kinase kinase 1 (SEK1) and c-Jun N-terminal kinase kinase 1 (JNKK1) (Dérijard et al., 1995). Description MKK4 gene is encoded by 11 exons located on chromosome 17p12. The genomic size is 122917 bp. Transcription mRNA size: 3752 bp; coding sequence from 1 bp-3743 bp. Pseudogene Pseudogene is located on Xq13.2. Protein Note The MKK4 cDNA has 1197 bp open reading frame encoding a predicted polypeptide of 399 amino acids with a predicted molecular mass of 67 kDa.