Jundishapur J Chronic Dis Care. 2024 July; 13(3):e143257. Published online 2024 February 26. https://doi.org/10.5812/jjcdc-143257. Letter Psychosocial Challenges of Parents with Children with Acute Lymphoblastic Leukemia Samira Beiranvand 1 , Sakineh Akbari 2, * and Amin Sattari 2 1 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2 Chronic Research Center, Jundishapur School of Nursing and Midwifery, Ahvaz, Iran * Corresponding author: Chronic Research Center, Jundishapur School of Nursing and Midwifery, Ahvaz, Iran. Email: sakineha60@gmail.com Received 2023 November 21; Accepted 2023 December 26. Keywords: Lymphoblastic Leukemi, Psychosocial Challenges, Children Dear Editor, Cancer is considered to be the second chronic non-communicable disease and the third cause of death in the world (1). Cancer in children is a global problem and the most important cause of death in this population (about 13%) after the accidents (2, 3). Acute leukemia is the most common type of cancer in children, and acute lymphoblastic leukemia (ALL) accounts for nearly 75% of cases (4). This leukemia specifically leads to the involvement of the precursors of B and T lymphocytes in the bone marrow and, as a result, prevents the differentiation of precursors of lymphoblasts in the early stages of differentiation (5). Failure to diagnose ALL on time might lead to its spread to different parts of the body, and if not treated on time, it might lead to the child’s death (6). Until the 1970s, only 60% of children with this disease had a life expectancy and survival of more than 5 years; however, currently, more than 90% of children with cancer survive more than 5 years due to standard treatments with high effectiveness (7). The complications and problems caused by this disease have imposed many costs on human societies in the fields of health, treatment, assistance, and welfare (8). After conducting clinical trials and providing supportive care, significant progress has been made in the recovery of children with ALL during the last two decades. However, patients with this disease are still at risk of death or illness caused by the disease and treatment (9). A child suffering from cancer puts parents under severe emotional stress and causes many psychological and social problems for them (10). At this time, children need attention and support more than ever, and the first source that can meet their needs is parents (11). Due to the chronic nature of cancer, children receive a large part of their treatment at home; this imposes more responsibilities on parents than parental responsibility (12). The new responsibilities imposed on parents have caused them to experience a sense of loss of control, stress, anxiety, depression, sleep disturbance, uncertainty, hopelessness, fear, and guilt (13), and it causes major damage to their psychological well-being and quality of life (14). The combination of these factors causes mothers of children with cancer to report a higher level of stress than mothers of children with other chronic diseases (15), which can lead to a decrease in their psychological adaptation (16). One of the sources of stress for parents as primary caregivers is the fear of losing their children and enduring distress (17), which creates significant changes in the role of the family, the functioning of the family, and the parenting process of parents. This issue might affect the compatibility of parents and children (18). Parents of children with cancer experience social challenges, such as a significant decrease in family income, job loss, marital problems, and divorce due to their more important role in caregiving (10). The studies conducted in this field are generally focused on psychosocial problems among cancer patients and especially parents (19). Akhtar et al.’s study (as cited in Khazaeli et al.) showed that depression is very common among mothers of children with leukemia and even more so than fathers (20). One of the issues that involve parents of children with cancer is bearing distress, which has been observed as an important structure in growth and a new insight into the initiation and maintenance of psychological injuries and Copyright © 2024, Beiranvand et al. This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.