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OJVR
Online Journal of Veterinary Research©
Volume 22 (1):1-6, 2018.
Effect of Omega 3 fatty acid on lead ion anodic current peak
in blood of rabbits measured by cyclic voltammetry.
Muhammed Mizher Radhi
1
, Bahaa Fakhri Hussein
2
, Ahmed Adeeb Mohamed
2
1. Radiology, Health and Medical Technology College-Baghdad, Middle Technology University, Iraq 2. College of Veterinary
Medicine, University of Baghdad, Baghdad, Iraq
ABSTRACT
Radhi MM, Hussein BF, Mohamed AA., Effect of Omega 3 fatty acid on lead ion anodic
current peak in blood of rabbits measured by cyclic voltammetry, Onl J Vet Res 22 (1):1-7,
2018. One cause of autism is lead contamination in pregnant women or children. We
describe effect of lead ions with or without omega 3 fatty acid supplement on anodic peak
currents (oxidation) measured by cyclic voltammetry in blood of groups of 5 NZ white
female rabbits each, 9 times for 9 weeks. The omega compound reduced (P < 0.05) current
oxidation peak of lead ions from 16.8 uA to 2.49 uA and concentration of lead ions in blood
12.138 to 0.353 mg/l. The findings suggest that omega may reduce lead ion oxidation in
blood of rabbits.
Keywords: Lead ions, Blood Medium, Cyclic Voltammetry, GCE, Omega3, Rabbit
INTRODUCTION
Lead ions can induce oxidation and creation of free radicals in human blood [1-5]. Omega-3
fatty acid inhibits lipid peroxidation in brain tissue in rats [7]. Differential pulse stripping
anodic voltammetry can measure concentration of lead and cadmium ions in samples of fish
[8]. Omega 3 fatty acid exhibits anti-oxidant effects in patients with kidney failure and is
given to hemodialysis patients [9]. Fish meal omega fatty acids reduce oxidant stress in
cardiovascular disease. [10, 11]. Recently, omega-3 polyunsaturated fatty acids was given to
rats with lead acetate-induced toxicity in liver and kidney of female rats causing elevation in
MDA and depletion of antioxidant enzymes in tissues confirmed by histopathological
changes and DNA damage [12]. We report effect of omega 3 fatty acid on lead ion anode
current peaks measured by cyclic voltammetry in blood of rabbits.