Bulletin of Electrical Engineering and Informatics Vol. 12, No. 5, October 2023, pp. 3075~3085 ISSN: 2302-9285, DOI: 10.11591/eei.v12i5.4837  3075 Journal homepage: http://beei.org Emerging development in polymeric electrospun nanoscale mats for tissue regeneration: narrative review of the literature Hamza Abu Owida 1 , Muhammad Al-Ayyad 1 , Jamal Al-Nabulsi 1 , Nidal Turab 2 , Mustafa Abdullah 3 1 Department of Medical Engineering, Faculty of Engineering, Al-Ahliyya Amman University, Amman, Jordan 2 Department of Networks and Cyber Security, Faculty of Information Technology, Al-Ahliyya Amman University, Amman, Jordan 3 Civil Engineering, Faculty of Engineering, Al-Ahliyya Amman University, Amman, Jordan Article Info ABSTRACT Article history: Received Sep 21, 2022 Revised Nov 29, 2022 Accepted Jan 29, 2023 Tissue engineering is a cutting-edge discipline that brings together scientific and health-related, biological, and engineering principles in order to build tissue-engineered constructions able to restore or sustain the physiological properties of native tissue, or to marginally enhance those properties. This field is called "regenerative medicine". By constructing structures that are analogous to the extracellular matrix, it will be possible to improve the transmission of oxygen and nutrients, as well as the release of toxins during the process of tissue healing, all while simultaneously maturing tissues. Over the past few years, various studies have concentrated on looking at nanostructures in three dimensions with the goal of using them in tissue engineering. In this group of methods, electrospinning stands out as one of the most successful options. Over the course of the past few decades, a great number of nanofibrous scaffolds have been produced for the purpose of restoring and repairing damaged tissue. In this article, the engineering of new tissues using nanofibrous textures as scaffolds are reviewed. In addition, recent developments in tissue regeneration and the difficulties related to electrospinning are discussed in this article, along with their respective solutions. Keywords: Electrospinning Nanofibers Scaffolds Tissue engineering This is an open access article under the CC BY-SA license. Corresponding Author: Nidal Turab Department of Networks and Cyber Security, Faculty of Information Technology Al-Ahliyya Amman University Amman, Jordan Email: N.turab@Ammanu.edu.jo 1. INTRODUCTION Since Nobel prize-winning physicist Richard Feynman proposed building small molecules bots, researchers have studied society's role in nanotechnology [1], [2]. Nanotechnology is the study and manipulation of objects on the "nano-scale" (1-100 nm) [3]. Recent nanotechnology advancements have established exceptionally high benchmarks in the life and health sciences [4]–[6]. To fabricate uniform nanofibers, electrospinning is a flexible and easy technique [7]. Electrospinning's allure stems mostly from the ease and adaptability of the equipment and production of nanofibers [8]. Explosive growth in tissue engineering over the past three decades has resulted in a plethora of novel therapeutic approaches meant to outperform more conventional methods of repairing injured live tissue [9], [10]. This method employs some elementary engineering, material science, and biology concepts to aid in the restoration of deficient living tissue [9]. The structural and mechanical properties of these nanofibers,