30 ɋɴɪɞɟɱɧɨ-ɫɴɞɨɜɢ ɡɚɛɨɥɹɜɚɧɢɹ, 45, 2014, ʋ 3 ȽȿɇɈɆɇɂɌȿ ȺɋɈɐɂȺɌɂȼɇɂ ɉɊɈɍɑȼȺɇɂə ɄȺɌɈ ɋɔȼɊȿɆȿɇȿɇ ɉɈȾɏɈȾ ɁȺ ɂɁəɋɇəȼȺɇȿ ɇȺ ȽȿɇȿɌɂɑɇɂɌȿ ɈɋɇɈȼɂ ɇȺ ȺɊɌȿɊɂȺɅɇȺɌȺ ɏɂɉȿɊɌɈɇɂə – ɑȺɋɌ ȼɌɈɊȺ Ɋ. ɐȼȿɈȼȺ 1, 2 , Ɍ. əɇȿȼȺ 3 , Ƚ. ȾɂɆɂɌɊɈȼ 3 , Ⱦ. ɉȿɇȾɂɑȿȼȺ-ȾɍɏɅȿɇɋɄȺ 5 , ɋ. ȼɔɇȾȿȼȺ 4 , Ƀ. ɆȺɌɊɈɁɈȼȺ 4 , Ʉ. ɇȺɃȾȿɇɈȼ 2 , Ɉ. ȻȿɅɑȿȼȺ 1, 2 , Ⱥ. ɆɂɌɄɈȼȺ 1, 2 , ɋ. ɁȺɏȺɊɂȿȼȺ 4 , Ɋ. ɌɔɊɇɈȼɋɄȺ-ɄɔȾɊȿȼȺ 3 , Ƚ. ɇȺɑȿȼ 6 , ȼ. ɆɂɌȿȼ 1, 2 ɂ Ɋ. ɄɔɇȿȼȺ 1, 2 1 ɐɟɧɬɴɪ ɩɨ ɦɨɥɟɤɭɥɧɚ ɦɟɞɢɰɢɧɚ, Ɇɟɞɢɰɢɧɫɤɢ ɭɧɢɜɟɪɫɢɬɟɬ – ɋɨɮɢɹ 2 Ʉɚɬɟɞɪɚ „Ɇɟɞɢɰɢɧɫɤɚ ɯɢɦɢɹ ɢ ɛɢɨɯɢɦɢɹ”, Ɇɟɞɢɰɢɧɫɤɢ ɭɧɢɜɟɪɫɢɬɟɬ – ɋɨɮɢɹ 3 Ʉɥɢɧɢɤɚ ɩɨ ɤɚɪɞɢɨɥɨɝɢɹ, ɍɆȻȺɅ „Ⱥɥɟɤɫɚɧɞɪɨɜɫɤɚ” – ɋɨɮɢɹ 4 Ʉɥɢɧɢɱɟɧ ɰɟɧɬɴɪ ɩɨ ɟɧɞɪɨɤɪɢɧɨɥɨɝɢɹ ɢ ɝɟɪɨɧɬɨɥɨɝɢɹ, Ɇɟɞɢɰɢɧɫɤɢ ɭɧɢɜɟɪɫɢɬɟɬ – ɋɨɮɢɹ 5 Ʉɚɬɟɞɪɚ „ȿɤɫɩɟɪɢɦɟɧɬɚɥɧɚ ɢ ɤɥɢɧɢɱɧɚ ɮɚɪɦɚɤɨɥɨɝɢɹ, ɞɟɪɦɚɬɨɥɨɝɢɹ ɢ ɜɟɧɟɪɨɥɨɝɢɹ”, Ɇɟɞɢɰɢɧɫɤɢ ɭɧɢɜɟɪɫɢɬɟɬ – ɉɥɟɜɟɧ 6 ɍɋȻȺɅɋɋɁ „ɋɜ. ȿɤɚɬɟɪɢɧɚ” – ɋɨɮɢɹ GENOME – WIDE ASSOCIATION STUDIES AS A CONTEMPORARY APPROACH TO DETERMINATION OF THE GENETIC BASIS OF ARTERIAL HYPERTENSION – PART TWO R. TZVEOVA 1, 2 , T. YANEVA 3 , G. DIMITROV 3 , D. PENDICHEVA-DUHLENSKA 5 , S. VANDEVA 4 , Y. MATROZOVA 4 , K. NAYDENOV 2 , O. BELTCHEVA 1, 2 , A. MITKOVA 1, 2 , S. ZACHARIEVA 4 , R. TURNOVSKA-KADREVA 3 , G. NACHEV 4 , V. MITEV 1, 2 AND R. KANEVA 1, 2 1 Molecular Medicine Center, Medical University – Soｿa 2 Department of Medical Chemistry and Biochemistry, Medical University – Soｿa 3 Clinic of Cardiology, University Hospital “Aleksandrovska” – Soｿa 4 Clinical Center of Endocrinology and Gerontology, Medical University – Soｿa 5 Department of Experimental and Clinical Pharmacology, Dermatology and Venereology, Medical University – Pleven 6 University National Specialized Hospital for Active Treatment Hospital “Sv. Ekaterina” – Soｿa Ɋɟɡɸɦɟ. Ⱥɪɬɟɪɢɚɥɧɚɬɚ ɯɢɩɟɪɬɨɧɢɹ (Ⱥɏ) ɩɪɟɞɫɬɚɜɥɹɜɚ ɨɫɧɨɜɟɧ ɫɴɪɞɟɱɧɨ-ɫɴɞɨɜ ɪɢɫɤɨɜ ɮɚɤɬɨɪ, ɨɬɝɨɜɨɪɟɧ ɡɚ ɧɚɞ 50% ɨɬ ɫɴɪɞɟɱɧɨ-ɫɴɞɨɜɚɬɚ ɡɚɛɨɥɹɟɦɨɫɬ ɢ ɫɦɴɪɬɧɨɫɬ ɩɨ ɰɟɥɢɹ ɫɜɹɬ, ɨɫɨɛɟɧɨ ɜ ɪɚɡɜɢɬɢɬɟ ɫɬɪɚɧɢ. ȿɩɢɞɟɦɢɨɥɨɝɢɱɧɢɬɟ ɞɚɧɧɢ ɨɬ ɝɨɥɹɦ ɛɪɨɣ ɩɪɨɭɱɜɚɧɢɹ ɩɨɤɚɡɜɚɬ, ɱɟ ɜɴɡ- ɧɢɤɜɚɧɟɬɨ ɧɚ Ⱥɏ ɫɟ ɞɴɥɠɢ ɧɚ ɟɞɧɨɜɪɟɦɟɧɧɨɬɨ ɢ ɤɨɦɛɢɧɢɪɚɧɨ ɜɥɢɹɧɢɟ ɧɚ ɝɟɧɟɬɢɱɧɢ ɮɚɤɬɨɪɢ ɢ ɮɚɤɬɨɪɢ ɧɚ ɩɪɨɦɟɧɹɳɚɬɚ ɫɟ ɨɤɨɥɧɚ ɫɪɟɞɚ. ɂɦɟɧɧɨ ɩɨɪɚɞɢ ɬɚɡɢ ɩɪɢɱɢɧɚ ɯɢɩɟɪɬɨɧɢɹɬɚ ɟ ɨɩɪɟ- ɞɟɥɟɧɚ ɤɚɬɨ ɤɨɦɩɥɟɤɫɧɨ, ɦɭɥɬɢɮɚɤɬɨɪɧɨ ɡɚɛɨɥɹɜɚɧɟ, ɩɪɢ ɤɨɟɬɨ ɞɟɥɴɬ ɧɚ ɝɟɧɟɬɢɱɧɢɹ ɤɨɦɩɨ- ɧɟɧɬ ɟ ɦɟɠɞɭ 30 ɢ 50%. ɉɴɪɜɢɹɬ ɨɩɢɬ ɡɚ ɩɪɨɜɟɠɞɚɧɟ ɧɚ ɲɢɪɨɤɨɦɚɳɚɛɧɨ, ɝɟɧɨɦɧɨ ɢɡɫɥɟɞɜɚɧɟ, ɢɦɚɳɨ ɡɚ ɰɟɥ ɞɚ ɢɞɟɧɬɢɮɢɰɢɪɚ ɝɟɧɢ ɢ ɝɟɧɧɢ ɥɨɤɭɫɢ, ɚɫɨɰɢɢɪɚɧɢ ɫ Ⱥɏ, ɟ ɧɚɩɪɚɜɟɧ ɩɪɟɡ 2007 ɝɨɞ. ɨɬ Welcome Trust Case Control Consortium, ɧɨ ɜɴɩɪɨɫɧɨɬɨ ɩɪɨɭɱɜɚɧɟ ɧɟ ɭɫɩɹɜɚ ɞɚ ɢɞɟɧɬɢɮɢɰɢɪɚ ɝɟɧɟɬɢɱɧɢ ɜɚɪɢɚɧɬɢ, ɩɨɜɢɲɚɜɚɳɢ ɱɭɜɫɬɜɢɬɟɥɧɨɫɬɬɚ ɤɴɦ ɜɢɫɨɤɢ ɫɬɨɣɧɨɫɬɢ ɧɚ Ⱥɏ ɩɪɢ ɟɜɪɨ- ɩɟɣɰɢ. Ɉɬ ɬɨɡɢ ɦɨɦɟɧɬ ɧɚɬɚɬɴɤ ɫɚ ɩɪɨɜɟɞɟɧɢ ɧɹɤɨɥɤɨ ɝɨɥɟɦɢ ɩɪɨɭɱɜɚɧɢɹ, ɩɨɤɪɢɜɚɳɢ ɰɟɥɢɹ ɱɨ- ɜɟɲɤɢ ɝɟɧɨɦ, ɤɚɬɨ ɫɚ ɢɞɟɧɬɢɮɢɰɢɪɚɧɢ ɧɚɞ 50 ɧɚ ɛɪɨɣ ɪɢɫɤɨɜɢ ɜɚɪɢɚɧɬɚ ɜ ɪɚɡɥɢɱɧɢ ɯɪɨɦɨɡɨɦɧɢ ɥɨɤɭɫɢ, ɫɜɴɪɡɚɧɢ ɫ ɩɪɨɦɟɧɢ ɜ ɫɬɨɣɧɨɫɬɢɬɟ ɧɚ ɫɢɫɬɨɥɧɨɬɨ ɢ ɞɢɚɫɬɨɥɧɨɬɨ ɚɪɬɟɪɢɚɥɧɨ ɧɚɥɹɝɚɧɟ (ɋȺɇ ɢ ȾȺɇ) ɢɥɢ Ⱥɏ ɤɚɬɨ ɰɹɥɨ. Ʉɥɸɱɨɜɢ ɞɭɦɢ: ɚɪɬɟɪɢɚɥɧɚ ɯɢɩɟɪɬɨɧɢɹ, ɦɭɥɬɢɮɚɤɬɨɪɧɨ ɡɚɛɨɥɹɜɚɧɟ, ɝɟɧɟɬɢɱɧɢ ɜɚɪɢɚɧɬɢ, ɯɪɨɦɨɡɨɦɧɢ ɥɨɤɭɫɢ Summary. Arterial hypertension (AH) is a major quantitative cardiovascular risk factor, responsible for over 50% of cardiovascular morbidity and mortality worldwide, especially in developed countries. Epidemiological data from a large number of studies have shown that the occurrence of hypertension is due to simultaneous and combined inﾀuence of genetic factors and the evolving environment. Arterial hypertension is deｿned as a complex, multifactorial disease, in which the proportion of the genetic